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Vulvar Carcinoma in Situ


Presentation

  • A hypothesis as to the clonal evolution of multicentric and confluent vulvar carcinoma is presented based on the authors' findings.[ncbi.nlm.nih.gov]
  • Multifocal disease was present in 59% of the cases. Lesions involving the posterior vulva recurred most commonly, for both initial and recurrent disease.[ncbi.nlm.nih.gov]
  • Associated VIN may be present at the margins. Well differentiated squamous cell carcinoma. Nests of tumor cells, some with keratin pearls, are present.[med-ed.virginia.edu]
  • The diagnostic procedure and therapy of carcinoma in situ of the vulva and the anal region are presented by reporting two cases of young women.[ncbi.nlm.nih.gov]
  • Abstract A new conservative method for treating carcinoma in situ of the vulva is presented. The carbon dioxide laser offers the advantage of a microsurgical technique combined with the benefits of sharp local excision.[ncbi.nlm.nih.gov]
Hyperthermia
  • .: 3 Case Report Photodynamic Therapy for Vulvar Carcinoma in situ (Case Report) Dmitry Tzerkovsky 1* 1 Laboratory of Photodynamic Therapy and Hyperthermia with Chemotherapy Group, N.N. Alexandrov National Cancer Center, Lesnoy, Republic of Belarus.[sciencedomain.org]
Chronic Cough
  • Symptoms of recurrent cancer may include bleeding, pain in the genitals, groin, pelvis or legs, leg swelling (edema), weight loss, chronic cough and chest pain.[womenscancercenter.com]
Chest Pain
  • Symptoms of recurrent cancer may include bleeding, pain in the genitals, groin, pelvis or legs, leg swelling (edema), weight loss, chronic cough and chest pain.[womenscancercenter.com]
Thrombosis
  • Complications of surgery include wound infection, sexual dysfunction, edema and thrombosis, as well as lymphedema secondary to dissected lymph nodes. [32] Sentinel lymph node (SLN) dissection is the identification of the main lymph node(s) draining the[en.wikipedia.org]
Photosensitivity
  • Keywords : Vulvar cancer in situ; photodynamic therapy; photosensitizer; photolon. Full Article - PDF Page 1-5 DOI : 10.9734/JCTI/2017/33532 Review History Comments[sciencedomain.org]
Excitement
  • It is capable of some enlargement caused by increased blood pressure during sexual excitement and is considered homologous (comparable in structure) to the male penis , only on a much smaller scale.[britannica.com]
  • The amount of discharge can vary from woman to woman, and you may notice more discharge when you're feeling sexually excited. It's normal for all women to get vaginal discharge throughout the month.[brook.org.uk]

Workup

  • 1859 Infectious Agents and Cancer 549 1860 Cancer of the Skin 1863 Melanoma 1889 Diagnostic Studies and Pretreatment Staging 1001 1908 Principles of Isolation Perfusion 701 1923 Intraocular Melanomas 1951 Invasion and Metastasis 117 1952 Metastatic WorkUp[books.google.com]
  • The patient was then referred to the gynecologic oncology service at our institution for further workup and management. She was noted to have extensive multifocal and multicentric disease ( Fig. 1 ).[ncbi.nlm.nih.gov]

Treatment

  • The CO2 laser is well suited for treatment of both multifocal and unifocal vulvar lesions, as it allows for maximal retention of vulvar integrity with no decrease in therapeutic efficacy.[ncbi.nlm.nih.gov]
  • Most experts agree that treatment in a clinical trial should be considered. This way women can get the best treatment available now and may also get the treatments that are thought to be even better.[cancer.org]
  • Types of treatment for cancer are either local or systemic. Local treatments remove, destroy, or control cancer cells in one area. Surgery and radiation are local treatments.[urmc.rochester.edu]
  • […] and effective treatment options.[ncbi.nlm.nih.gov]

Prognosis

  • Although large, multicentre studies are needed to definitively assess the involvement of HPV in the prognosis of VSCC, most studies have not found clear differences in survival between HPV-associated and HPV-independent tumours.[unboundmedicine.com]
  • Grade I (mature, or well-differentiated) cancers have a better prognosis than grade 3 (poorly-differentiated) tumors.[womenscancercenter.com]
  • The HPV status may act as a biomarker for predicting the prognosis of patients with vulvar cancer.[journals.plos.org]
  • The sooner cancer of the vulva is diagnosed, the faster it can be treated and the better the patient's prognosis (see vulva cancer survival rates ).[womens-health-advice.com]

Etiology

  • Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology.[icd10coded.com]
  • These data suggest that vulvar cancer has a diverse etiology which in young women in HPv-related but in older women has little association with HPV.[insights.ovid.com]
  • […] classified as human papillomavirus (HPV) associated or non-HPV associated, replacing the current nomenclature ( Histopathology 2013;62:161 ) Terminology Synonym: condylomatous carcinoma Often considered along with basaloid carcinoma of vulva due to common etiology[pathologyoutlines.com]
  • In addition, 2 case series 11, 12 of patients with anogenital carcinoma were found in which the authors investigated the underlying etiology of the malignancy.[jamanetwork.com]
  • ( J Cutan Pathol 1980;7:244 ) Usual or classic vulvar intraepithelial neoplasia Sites Often involves labia majora but can be multifocal affecting various parts of vulva May involve other squamous epithelia such as cervical, vaginal and anal mucosae Etiology[pathologyoutlines.com]

Epidemiology

  • Attention was focused upon the epidemiology, duration of symptoms, and location of lesions.[ncbi.nlm.nih.gov]
  • METHODS: We used the Surveillance Epidemiology and End Results database to assess trends in the incidence of vulvar cancer over a 28-year period (1973 through 2000) and determined whether there had been a change in incidence over time.[mayoclinic.pure.elsevier.com]
  • Invasive squamous cell carcinoma Epidemiology Squamous cell carcinoma is the commonest malignant tumor of the vulva, representing about 95% of all vulvar malignancies.[med-ed.virginia.edu]
  • These two different types of VSCC have different epidemiological, pathological and clinical characteristics, and should therefore be considered as two separate entities.[unboundmedicine.com]
  • Author Affiliations From the departments of Obstetrics and Gynecology and Virology and Epidemiology, Baylor College of Medicine; the Department of Microbiology, University of Leeds, Leeds, England; and the Department of Microbiology, University of Tennessee[nejm.org]
Sex distribution
Age distribution

Pathophysiology

  • Pathophysiology: Functional Alterations in Human Health. Lippincott Williams & Wilkins. ISBN 9780781762502. Rubin, Emanuel; Reisner, Howard M. (2009). Essentials of Rubin's Pathology. Lippincott Williams & Wilkins.[en.wikipedia.org]
  • Adenocarcinoma can arise from the Bartholin gland and present with a painful lump. [11] Causes [ edit ] Two main pathophysiological pathways are currently understood to contribute to development of vulvar cancer - human papillomavirus (HPV) infection[en.wikipedia.org]
  • Porth pathophysiology: concepts of altered health states (1st Canadian ed.). Philadelphia, PA: Wolters Kluwer Health/Lippincott Williams & Wilkins. p. 660. ISBN 978-1-60547-781-7. Robbins S, Kumar V, Abbas A, Fausto N (2007).[en.wikipedia.org]
  • Pathophysiology [ edit ] Although it is not clear what causes LS, several theories have been postulated.[en.wikipedia.org]
  • Sexual dysfunction in women: An overview of psychological/psycho-social, pathophysiological, etiological aspects and treatment strategies. Pharmacognosy Rev., 1: 41-48. Direct Link Rasspagliesi, F., A. Ditto, R. Fontanelli, M. Maccauro, M.L.[scialert.net]

Prevention

  • Strategies to Enhance Access to Health Care 88 Dynamics of Cancer Prevention 95 Cancer Prevention and Public Policy 108 Screening and Detection for Asymptomatic Individuals 115 Oral Communication of Risk 122 Jennifer T Loud RN CRNP DNP Sadie P Hutson[books.google.com]
  • Avoiding the risk factors is most important in the prevention of VIN and its progression to invasive cancer. In addition, thorough management of associated disorders and screening for VIN are necessary, especially in high-risk individuals.[oncologynurseadvisor.com]
  • Differentiated VIN can be prevented by the appropriate treatment of associated vulvar skin disorders, such as lichen sclerosis.[cancer.columbia.edu]
  • Massad to discuss the subject of VIN at length, elaborating on key issues such as its prevention, identification, treatment, and surveillance. OBG Management: What is VIN? What does it look like? Dr.[mdedge.com]

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