Int J Gynecol Cancer 2002;12(5):490-5] against proposed performance indicators to illustrate the deficiencies in current data presentation. [ncbi.nlm.nih.gov]

Apoptotic keratinocytes are present. Granular yellow pigment (hemosiderin?) is present in the epidermis. The epidermis is not significantly thickened. The lesional cells extend to the lateral edges of the tissue. [librepathology.org]

• Weakness

  ViroChip analysis of 10 pure dVIN samples confirmed the absence of human papillomavirus subtypes or any other virus with the exception of a single sample that showed a weak microarray signature to a porcine herpesvirus. [ncbi.nlm.nih.gov]

  NEGATIVE: HMB-45, S-100, p53 (weak, patchy, superficial squamous cells). PROLIFERATION (Ki-67): increased, marks superficial squamous cells (compatible with high-grade lesion). Micro The sections show a punch biopsy of skin. [librepathology.org]

• Asymptomatic

  The presence of polyfunctional anti-E2 T-cell responses in the blood of asymptomatic men unambiguously establishes HPV infection even without detectable lesions. [ncbi.nlm.nih.gov]

  Owing to the fact that 40-50 per cent of patients are asymptomatic, the standard of diagnosis remains visualisation and biopsy of all suspect vulval lesions. 2 VIN may be diagnosed by various healthcare providers, including dermatologists, gynaecologists [oncologynurseadvisor.com]

  The lesion is occasionally pruritic but is generally asymptomatic. She found it approximately 6 months ago, and it has been slowly increasing in size. There is no significant family history of cancer. [mhmedical.com]

  Roughly 20% of the women stay asymptomatic to the disease, which is diagnosed by chance during internal medical examination. [news-medical.net]

• Surgical Procedure

  The patients assessed with the FSFI regained normal sexual function after the surgical procedure. [ncbi.nlm.nih.gov]

  Extent of surgery [ Time Frame: 12 months ] The number, types and extent of surgical procedures will be recorded. [clinicaltrials.gov]

  Alternative surgical procedures that might be as effective include CUSA (ultrasonic surgical aspiration ) and LEEP (loop electrosurgical excision procedure), based on low- to very low-quality evidence, respectively. [cochrane.org]

  Wide local excision: A surgical procedure to remove the cancer and some of the normal tissue around the cancer. Radical local excision: A surgical procedure to remove the cancer and a large amount of normal tissue around it. [northshore.org]

  or surgical excision (27 procedures). [cochranelibrary.com]

• Ulcer

  We report here concomitant VIN3 and genital ulcers in a patient with BD. A 44-year-old Caucasian woman with a history of BD, which had been evolving for 6 years, presented with ulcerated and papillomatous lesions on the vulva. [ncbi.nlm.nih.gov]

  Figure 87-3 Diffuse white vulvar intraepithelial neoplasia III with ulceration. ( Courtesy of Hope Haefner, MD .) Figure 87-4 A small painful ulcer turned out to be vulvar intraepithelial neoplasia II on punch biopsy. [basicmedicalkey.com]

  The presence of a well-defined mass and symptoms like ulceration and bleeding strongly state VIN to be an invasive disease. [news-medical.net]

  […] vulva ) References: [2] Clinical features May initially be asymptomatic Local pruritus, possibly with burning sensation and pain Reddish, blackish, and/or whitish patches of discoloration Lumps or growths of various shapes, often wart-like lesions or ulcers [amboss.com]

• Skin Disease

  Immunosuppression by disease, such as human immunodeficiency virus ( HIV ) infection, or medications, such as those taken by organ transplant recipients. dVIN dVIN is associated with chronic vulval inflammatory skin disease, particularly lichen sclerosus [dermnetnz.org]

  What it is Vulval intraepithelial neoplasia (VIN) is a skin disease. Abnormal cells develop in the surface layers of the skin covering the vulva. It is not vulval cancer but could turn into a cancer. This may take many years. [cancerresearchuk.org]

  New nomenclature for vulvar disease: Report of the Committee on Terminology. Obstet Gynecol 1976; 147 :122. 20. Ridley CM, Frankman O, Jones IS, et al. New nomenclature for vulvar disease: international society for the study of vulvar disease. [nature.com]

• Skin Rash

  Other women can have various symptoms, including: • Severe vulvar pain • Severe vulvar itching • A lump at the vulva • Thickening skin at the vulva • A raised skin rash around the vulva (that looks similar to warts) • Tingling sensation of the vulva • [empowher.com]

• Freckles

  About 25% of lesions are hyperpigmented, appearing darkened like a mole or freckle. These more advanced, but noncancerous changes such as VIN III (carcinoma in situ) or actual cancer tend to occur at older ages. [wdxcyber.com]

• Confusion

  And yet when the doctor says that a biopsy of the vulva is needed to make sure there is not a malignancy or changes that could become malignant, confusion and lack of knowledge are the rule. [wdxcyber.com]

  Although this makes the literature confusing at times, ultimately it will help to ensure that the correct patients are enrolled into future studies as previous classifications may have included patients who would no longer be considered to have VIN today [evidentlycochrane.net]

  The differentiated vulvar intraepithelial neoplasia which is frequently seen together with the invasive squamous cell carcinoma can be confused with some benign lesions. [hoajonline.com]

  This is important because the leading edge of thermonecrosis produces a confusing pseudowhite appearance. [glowm.com]

• Burning Sensation

  Clinical manifestations of vulvar cancer include new lumps or lesions, itching, a burning sensation and, less frequently, vulvar bleeding. [amboss.com]

  Common symptoms are the presence of raised patches of red, gray, white, or dark color, warty skin, itching in the vulvar skin tissue, burning sensation while urinating, and pain in the vulvar skin. [news-medical.net]

• Vulvar Pain

  Symptoms Symptoms are vulvar pain, itching, or burning. Risk factors include exposure to Human Papilloma Virus 16 and 18, type 2 Herpes Simplex Virus, and smoking. Diagnosis Diagnosis is made by biopsy of the lesion. [medical-dictionary.thefreedictionary.com]

  Erythema and vulvar pain may limit use. Experience with imiquimod in immunosuppressed patients is limited. Because it is believed to act through local immunomodulators, it may have decreased effectiveness in women who are immunocompromised. [acog.org]

• Genital Lesions

  Inadequacy of standard treatment of genital lesions in HIV+ patients. Int J Gynecol Obstet 1994;47:273 35 Spitzer M. Lower genital tract intraepithelial neoplasia in HIV-infected women: Guidelines for evaluation and management. [glowm.com]

Numbers of primary treatments were well described but the indications for treatment, completeness of excision and VIN subclassification were not. [ncbi.nlm.nih.gov]

Although large, multicentre studies are needed to definitively assess the involvement of HPV in the prognosis of VSCC, most studies have not found clear differences in survival between HPV-associated and HPV-independent tumours. © 2012 Blackwell Publishing [ncbi.nlm.nih.gov]

Vulvar cancer is usually associated with a poor prognosis. [amboss.com]

How to help yourself if you have been diagnosed with VIN Stop smoking – it has a direct link with VIN HPV vaccines have shown to decrease the risk of VIN, cervical cancer, and genital warts Treat or manage underlying lichen sclerosus when present The prognosis [allthingsvagina.com]

Hording U, et al: Human papillomavirus in vulvar squamous-cell carcinoma and in normal vulvar tissues: a search for a possible impact of HPV on vulvar cancer prognosis. Int J Cancer 1993;55:394–396. [karger.com]

Vulvar intraepithelial neoplasia (VIN) generally can be classified into viral and nonviral etiologies. The histopathologic diagnosis is often separable into basaloid and warty types. [ncbi.nlm.nih.gov]

Vaginal cancer is closely related to vulvar cancer in terms of etiology and histology, but it occurs inside the vagina (typically the posterior third of the vaginal wall), rather than the vulva. [amboss.com]

[…] in a background of lichen sclerosus and chronic inflammatory dermatoses Risk factors include older age, irritation, inflammation, oxidative and ischemic stress Sites Usually confined to nonhair bearing areas or external sides of atrophic labia minora Etiology [pathologyoutlines.com]

This review describes the relevant aspects of squamous VIN, vulvar Paget's disease and melanoma in situ, its epidemiological characteristics, diagnosis, management and malignant potential. [ncbi.nlm.nih.gov]

This may be the result of improved surveillance and treatment of VIN, or the apparent increase in cases of VIN in younger women. 3 Etiology and Pathophysiology VIN is the associated preneoplastic condition that is associated with the loss of epithelial [basicmedicalkey.com]

Objectives: Describe the pathophysiology of vulvar intraepithelial neoplasia. Identify risk factors for developing vulvar intraepithelial neoplasia. Identify the etiology of the vulvar lesion. [ncbi.nlm.nih.gov]

These features prevent the drawing of a direct analogy between vulvar and cervical intraepithelial neoplasia. [jcp.bmj.com]

The goal is to prevent development of invasive vulvar cancer while preserving normal vulvar anatomy and function. The authors describe the case of a 37-year-old woman affected by a biopsy-proven VIN 3 involving the entire external genitalia. [ncbi.nlm.nih.gov]

KEY WORDS: Empowerment - Behavior - Cervical cancer prevention - Women of childbearing age. Last Issue Toc Last Viewed [giog.it]