Presentation
Zum Verlinken/Zitieren: Englisch The present study examined the effects of proteasome inhibitors on Wallerian degeneration (WD) in the peripheral nervous system on the example of sciatic nerve sectioning in vivo and on the basis of nerve-macrophage co-cultures [ediss.uni-goettingen.de]
Consistent with this hypothesis, in vivo tracing of GFP-tagged WldS protein in uninjured nerves shows that WldS is normally present in axonal regions where Nmnat2 is also expressed. [jcb.rupress.org]
Entire Body System
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Falling
Alternatively, nerve injury may impair the transport or expression of an axonal trophic factor, causing the molecule to fall below a critical threshold to support axonal integrity and function ( Lubińska, 1982 ; Coleman, 2005 ). [jcb.rupress.org]
Neurologic
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Stroke
DOI: 10.1083/jcb.201108111 Published January 9, 2012 Abstract Axon degeneration is a characteristic event in many neurodegenerative conditions including stroke, glaucoma, and motor neuropathies. [jcb.rupress.org]
Workup
Other Pathologies
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Gliosis
It is seen as a contiguous tract of gliosis leading from a region of cortical or subcortical neuronal injury towards the deep cerebral structures, along the expected topographical course of the involved white matter tract. [radiopaedia.org]
Prevention
Channel-mediated influx of extracellular Ca 2 is critical for initiating AAD, as Ca 2 channel blockers prevent the early intra-axonal rise in Ca 2 and attenuate the progression of AAD. [jcb.rupress.org]