Alternatively, nerve injury may impair the transport or expression of an axonal trophic factor, causing the molecule to fall below a critical threshold to support axonal integrity and function ( Lubińska, 1982 ; Coleman, 2005 ). [jcb.rupress.org]

DOI: 10.1083/jcb.201108111 Published January 9, 2012 Abstract Axon degeneration is a characteristic event in many neurodegenerative conditions including stroke, glaucoma, and motor neuropathies. [jcb.rupress.org]

It is seen as a contiguous tract of gliosis leading from a region of cortical or subcortical neuronal injury towards the deep cerebral structures, along the expected topographical course of the involved white matter tract. [radiopaedia.org]