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Well-Differentiated Liposarcoma

ALT


Presentation

  • We present a rare case of recurrent well-differentiated liposarcoma, which re-occurred 26 years after initial presentation, having presented non-acutely on both occasions with dyspnoea, progressive dysphonia and intermittent stridor due to a valve-like[ncbi.nlm.nih.gov]
Inguinal Mass
  • A 69-year-old man was admitted with a complaint of left irreducible inguinal mass.[ncbi.nlm.nih.gov]
  • ISSN 1971-145X Abstract A 69-year-old man was admitted with a complaint of left irreducible inguinal mass.[eprints.bice.rm.cnr.it]
Suggestibility
  • The findings from this case suggest that even for a lipomatous tumor in the digits, further imaging examination and resection biopsy should be considered if the tumor presents with features that are atypical of lipomas.[ncbi.nlm.nih.gov]
Neck Mass
  • A 24-year-old female presented to the ears, nose and throat clinic for evaluation of a recent, rapidly growing neck mass on the right side.[ncbi.nlm.nih.gov]
  • Case Report A 56 year old male presented to surgery outpatient department with a progressively increasing left sided neck mass. This was noticed one year prior to presentation which was small initially and gradually increased to the present size.[austinpublishinggroup.com]

Treatment

  • The treatment of DDLS patients proves to be complicated due to the fact that the histopathological diagnosis usually becomes evident only after the surgery.[ncbi.nlm.nih.gov]

Prognosis

  • The dedifferentiated liposarcomas (DDLS) have a better prognosis than pleomorphic sarcomas as a whole.[ncbi.nlm.nih.gov]
  • The prognosis of WDLS depends on tumor location. WDLS arising from extremities usually has a good prognosis after removal of the tumor, with a low risk of recurrence and low mortality.[radiopaedia.org]
  • What is the Prognosis of Well-Differentiated Liposarcoma? (Outcomes/Resolutions) The prognosis is excellent with early surgical intervention.[dovemed.com]

Etiology

  • (Etiology) The exact cause and mechanism of formation of Well-Differentiated Liposarcoma is unknown It is thought to occur spontaneously due to certain genetic mutations (chromosomal abnormalities) Contrary to some beliefs, trauma does not contribute[dovemed.com]
  • Hyperattenuating renal masses: Etiologies, pathogenesis, and imaging evaluation. Radiographics 2007; 27:1131–1143 CrossRef PubMed Google Scholar Articoli Vie urinarie Berrocal T, López-Pereira P, Arjonilla A, Gutiérrez J.[link.springer.com]

Epidemiology

  • METHODS: We identified 1266 patients with WD Lipo in the Surveillance, Epidemiology, and End Results database from 1988-2004.[ncbi.nlm.nih.gov]
  • Epidemiology 5000 new cases/year (US), which is 20% of all soft-tissue tumours; average age 50, slightly more common in males.[medical-dictionary.thefreedictionary.com]
  • Epidemiology There is the largest group of locally aggressive lipomatous tumours. It usually occurs in middle age. Macroscopic appearances Usually forming a well circumscribed mass, may sometimes be infiltrative.[e-immunohistochemistry.info]
  • Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978–2001: an analysis of 26 758 cases .[cambridge.org]
  • Epidemiology Well-differentiated liposarcomas account for 40-45% of all liposarcomas and are usually diagnosed after the fifth decade of life; slight male predominance has been reported.[atlasgeneticsoncology.org]
Sex distribution
Age distribution

Pathophysiology

  • Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test The histological discrimination of well-differentiated liposarcoma/atypical lipomatous tumor (WDL/ALT) from lipoma can be diagnostically[mayomedicallaboratories.com]

Prevention

  • Awareness of the existence of this variant of inflammatory liposarcoma should prevent its misinterpretation as a primary lymphoproliferative process.[ncbi.nlm.nih.gov]
  • WD liposarcoma and atypical lipoma should be considered as synonyms and their use should therefore be determined by the degree of reciprocal comprehension between the surgeon and the pathologist to prevent either inadequate or excessive treatment.[scienceopen.com]

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