We present a rare case of recurrent well-differentiated liposarcoma, which re-occurred 26 years after initial presentation, having presented non-acutely on both occasions with dyspnoea, progressive dysphonia and intermittent stridor due to a valve-like [ncbi.nlm.nih.gov]

• Pathologist

  Copyright information: BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved. [jcp.bmj.com]

  A soft tissue pathologist, blinded to prior diagnosis and clinical outcome, reviewed histology. Those composed predominantly of mature adipose tissue with scattered atypical stromal cells and scant lipoblasts or fibrosis were ALTs. [ncbi.nlm.nih.gov]

  […] under the microscope Inflammatory Well-Differentiated Liposarcoma: Prominent inflammatory cells are found in the tumor, when it is examined by a pathologist under the microscope Spindle Cell Well-Differentiated Liposarcoma: In addition to the retroperitoneum [dovemed.com]

  WD liposarcoma and atypical lipoma should be considered as synonyms and their use should therefore be determined by the degree of reciprocal comprehension between the surgeon and the pathologist to prevent either inadequate or excessive treatment. [scienceopen.com]

• Swelling

  Males aged 60 and 45 years presented with a swelling in the groin and retroperitoneal region, respectively. FNAC showed large cells with multilobulated nuclei and mature-looking fat tissue. [ncbi.nlm.nih.gov]

  Abstract A 45 year old female presented with huge abdominal swelling (subsequently diagnosed as a retroperitoneal mass (12kg) by ultrasonogram and CT scan), gradual weight loss and respiratory distress for last one year. [banglajol.info]

  Clinical findings Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome. [medical-dictionary.thefreedictionary.com]

  Local examination showed 8x7 cm, non-tender, ill defined, soft to firm, pseudofluctuant subcutaneous swelling in the neck. It was extending from midline to the angle of mandible. Overlying skin was unremarkable. [austinpublishinggroup.com]

  Physical examination revealed a nodular swelling in the superficial soft tissue of the left thigh m/s 9x8cm and a pre operative diagnosis of lipoma was made. [recentscientific.com]

• Inflammation

  […] pleomorphic lipoma They do not recur aggressively or dedifferentiate Atypical lipomatous tumor does occur rarely in other subcutaneous sites If a high grade sarcomatous component is present, designate the process as dedifferentiated liposarcoma Chronic inflammation [surgpathcriteria.stanford.edu]

  Multiple biopsies were obtained but were all superficial, showing unspecific inflammation of the gastric mucosa. [panafrican-med-journal.com]

• Surgical Procedure

  The blood loss during surgery was acceptable (150 to 220 mL), mean time for surgical procedure was 140 min, and the duration of hospital stay ranged from 4 to 6 days. [wjso.biomedcentral.com]

  Due to the benign nature of this lesion an extensive surgical procedure such as an extended gastrectomy is not necessary. [panafrican-med-journal.com]

  Consultations Consultation with the following specialists may be warranted: Oncologist: When malignancy is strongly suspected or when previous incisional biopsy reveals liposarcoma, consultation with an oncologist prior to the definitive surgical procedure [emedicine.medscape.com]

• Fever

  The patient denied any history of gastrointestinal hemorrhage, nausea, vomiting, and change in bowel habits, fevers, or melena. Physical examination was unremarkable. [panafrican-med-journal.com]

• Abdominal Pain

  A 61 year-old male patient admitted with one-year history of abdominal pain, distention. [ncbi.nlm.nih.gov]

  Clinical findings Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome. [medical-dictionary.thefreedictionary.com]

  Overall, the most important clinical finding is palpable abdominal mass and abdominal pain. [wjso.biomedcentral.com]

  Only when the tumor is very large do symptoms of pain or functional disturbances occur. Retroperitoneal tumors may present themselves with signs of weight loss and emaciation and abdominal pain. [en.wikipedia.org]

  Complications from Well-Differentiated Liposarcomas may include the following: Large tumors in the retroperitoneal cavity can lead to weight loss, abdominal pain, frequent urination, and kidney failure due to compression of the kidney Tumors in the leg [dovemed.com]

• Nausea

  Clinical findings Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome. [medical-dictionary.thefreedictionary.com]

  The patient denied any history of gastrointestinal hemorrhage, nausea, vomiting, and change in bowel habits, fevers, or melena. Physical examination was unremarkable. [panafrican-med-journal.com]

• Vomiting

  Clinical findings Mass, history of trauma, swelling, reduced range of motion, increased varicose veins, fatigue, abdominal pain, nausea, vomiting, weight loss, compartment syndrome. [medical-dictionary.thefreedictionary.com]

  The patient denied any history of gastrointestinal hemorrhage, nausea, vomiting, and change in bowel habits, fevers, or melena. Physical examination was unremarkable. [panafrican-med-journal.com]

• Fracture

  Periosteal stripping should be avoided, if possible, because it may increase the risk of a later radiation-related pathologic fracture, particularly of the femur 13. [docmh.com]

• Suggestibility

  The tight correlation between the presence of ring chromosomes and both amplification and overexpression of MDM2 and CDK4 genes suggests the exploration of the possibility that immunocytochemistry (ICC) might assist in the differential diagnosis of lipoma-like [ncbi.nlm.nih.gov]

The treatment of DDLS patients proves to be complicated due to the fact that the histopathological diagnosis usually becomes evident only after the surgery. [ncbi.nlm.nih.gov]

Surgical resection is the mainstay of treatment. Adjuvant radiation is considered for close margins. Survival for extremity tumors is favorable. [scholars.northwestern.edu]

The prognosis of WDLS depends on tumor location. WDLS arising from extremities usually has a good prognosis after removal of the tumor, with a low risk of recurrence and low mortality. [radiopaedia.org]

The dedifferentiated liposarcomas (DDLS) have a better prognosis than pleomorphic sarcomas as a whole. [ncbi.nlm.nih.gov]

What is the Prognosis of Well-Differentiated Liposarcoma? (Outcomes/Resolutions) The prognosis is excellent with early surgical intervention. [dovemed.com]

(Etiology) The exact cause and mechanism of formation of Well-Differentiated Liposarcoma is unknown It is thought to occur spontaneously due to certain genetic mutations (chromosomal abnormalities) Contrary to some beliefs, trauma does not contribute [dovemed.com]

Hyperattenuating renal masses: Etiologies, pathogenesis, and imaging evaluation. Radiographics 2007; 27:1131–1143 CrossRef PubMed Google Scholar Articoli Vie urinarie Berrocal T, López-Pereira P, Arjonilla A, Gutiérrez J. [link.springer.com]

METHODS: We identified 1266 patients with WD Lipo in the Surveillance, Epidemiology, and End Results database from 1988-2004. [ncbi.nlm.nih.gov]

Epidemiology 5000 new cases/year (US), which is 20% of all soft-tissue tumours; average age 50, slightly more common in males. [medical-dictionary.thefreedictionary.com]

Epidemiology There is the largest group of locally aggressive lipomatous tumours. It usually occurs in middle age. Macroscopic appearances Usually forming a well circumscribed mass, may sometimes be infiltrative. [e-immunohistochemistry.info]

Incidence patterns of soft tissue sarcomas, regardless of primary site, in the surveillance, epidemiology and end results program, 1978–2001: an analysis of 26 758 cases. [cambridge.org]

Well-differentiated liposarcomas treated with surgery, intraoperative distilled water lavage [7] and radiation have a low recurrence rate (about 10%) and rarely metastasize. [8] Five-year survival rates vary from 56 to 100% based on histological subtype. [8] Epidemiology [en.wikipedia.org]

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test The histological discrimination of well-differentiated liposarcoma/atypical lipomatous tumor (WDL/ALT) from lipoma can be diagnostically [mayomedicallaboratories.com]

A CT scan must be considered any time a rare form of hernia is observed and the surgical treatment of a retroperitoneal lipoma has to be radical, to prevent a recurrence. [ncbi.nlm.nih.gov]

WD liposarcoma and atypical lipoma should be considered as synonyms and their use should therefore be determined by the degree of reciprocal comprehension between the surgeon and the pathologist to prevent either inadequate or excessive treatment. [scienceopen.com]