Presentation
Some are non-syndromic while in others, a syndromic phenotype is present. [latunisiemedicale.com]
Treatment
Metformin as targeted treatment in fragile X syndrome. Clin Genet. 2017;93(2):216-22. DOI: https://doi.org/10.1111/cge.13039 [ Links ] 50. Castagnola S, Bardoni B, Maurin T. [scielo.org.co]
In addition to pharmaceutical intervention, one should not forget the positive effects that can be obtained by conventional ‘treatment’, offering MR individuals a stimulating and activating environment. [latunisiemedicale.com]
Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis. Salud Pública México. 2008;50:132-41. [ Links ] 29. Maulik PK, Darmstadt GL. [scielo.org.pe]
Prognosis
Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis. Salud Pública México. 2008;50:132-41. [ Links ] 29. Maulik PK, Darmstadt GL. [scielo.org.pe]
Etiology
Intellectual disability: definition, etiological factors, classification, diagnosis, treatment and prognosis. Salud Pública México. 2008;50:132-41. [ Links ] 29. Maulik PK, Darmstadt GL. [scielo.org.pe]
Epidemiology
Epidemiology of fragile X syndrome: a systematic review and meta-analysis. Am J Med Genet A. 2014;164A(7):1648-58. DOI: https://doi.org/10.1002/ajmg.a.36511 [ Links ] 13. [scielo.org.co]
Childhood disability in low- and middle-income countries: Overview of screening, prevention, services, legislation, and epidemiology. Pediatrics. 2007;120 (Supplement 1):S1-55. [ Links ] 30. Mercadante MT, Evans-Lacko S, Paula CS. [scielo.org.pe]
Pathophysiology
A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders. Front Cell Neurosci. 2015;9:280. DOI: https://doi.org/10.3389/fn-cel.2015.00280 [ Links ] 49. [scielo.org.co]
The pathophysiological processes of MR in the human brain are very complex and, have most probably started already in early pregnancy. [latunisiemedicale.com]
Prevention
Prevention of intellectual and developmental disabilities. Intellect Dev Disabil. 2009; 47(4):320-2. [ Links ] 79. Calderón-González R, Calderón-Sepúlveda RF. Prevention of mental retardation. Rev Neurol. 2003;36(2):184-94. [ Links ] 80. [scielo.org.pe]
Fragile X Syndrome: Prevalence, Treatment, and Prevention in China. Front. Neurol. 2017;8:1-7. DOI: https://doi.org/10.3389/fneur.2017.00254 [ Links ] 16. Beresford RG, Tatlidir C, Riddell DC, Welch JP, Ludman MD, Neumann PE, et al. [scielo.org.co]