Osteoporosis-Pseudoglioma Syndrome Clinical Characteristics Ocular Features: Retrolental masses often present at birth have been mistaken for retinoblastomas. [disorders.eyes.arizona.edu]

The 2nd revised edition of ‘Calcium and Bone Disorders in Children and Adolescents’ presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology, diagnosis and management of numerous conditions including [books.google.com]

In cases where osteoporosis is present, the holes and spaces in the honeycomb appear much bigger than those found in a healthy bone. Women and older adults are more at risk for developing osteoporosis. [radiologyinfo.org]

Review both the current surgical and medical clinical care paradigms for patients presenting with Atypical Femur fractures. Length: 60 minutes [asbmr.org]

Results: Hemizygous male carriers presented with multiple peripheral bone fractures, low bone mineral density (BMD), and vertebral compression fractures. [karger.com]

• Male Hypogonadism

  Men do not undergo the equivalent of menopause, but gonadal function does decrease in some elderly men, and overt male hypogonadism often is associated with vertebral fractures. 28 A large number of trials have compared estrogens with placebos and other [nap.edu]

  Overall, osteoporosis has a female-to-male ratio of 4:1. [emedicine.medscape.com]

• Cough

  Coughing and sneezing can also make the pain increase. Although the pain may move to other areas of the body (for example, into the abdomen or down the legs), this is uncommon. [orthoinfo.aaos.org]

  Anyone who has had a vertebroplasty and is experiencing chest pain, shortness of breath, pain with deep breathes, or pain with coughing should seek medical attention immediately. [healthcentral.com]

  Sometimes a cough or sneeze can cause a rib fracture or the partial collapse of one of the bones of the spine. Osteoporosis isn't usually painful until a fracture occurs, but spinal fractures are a common cause of long-term (chronic) pain. [nhs.uk]

  Overview Osteoporosis causes bones to become weak and brittle — so brittle that a fall or even mild stresses such as bending over or coughing can cause a fracture. Osteoporosis-related fractures most commonly occur in the hip, wrist or spine. [mayoclinic.org]

  There are often no symptoms or outward signs, and a person may not know they have it until they experience a fracture after a minor incident, such as a fall, or even a cough or sneeze. [medicalnewstoday.com]

• Constipation

  The side-effects of taking bisphosphonates, can include indigestion, a change in bowel habits (constipation or diarrhoea), tiredness, dizziness or headaches, aches and pains, swelling of the legs, feeling sick and flu-like symptoms. [yourhormones.info]

  Side effects are indigestion and constipation. If constipation and indigestion occur with calcium carbonate supplements, calcium citrate (Citracal) can be used. Some patients have difficulty swallowing calcium tablets. [medicinenet.com]

• Heart Disease

  Their study was published in the Journal of the American Geriatrics Society .The research team examined data from the Women's Health Initiative study, a large study that began in 1993 to develop ways to reduce heart disease, cancer, and fractures in women [sciencedaily.com]

  It is a known risk factor for heart disease because heart disease is largely an inflammatory disorder. [betterbones.com]

  Although yet unclear, some experts suggest that too much calcium especially in supplements can increase the risk of heart disease. [mayoclinic.org]

  […] syndrome Harrod syndrome Heart-hand syndrome Heart-hand syndrome type 2 Heart-hand syndrome type 3 Heart-hand syndrome, Slovenian type Hemimelia Hennekam syndrome Hepatic fibrosis-renal cysts-intellectual disability syndrome Hereditary breast cancer [se-atlas.de]

  Although the potential cardiovascular benefits of estrogen are likely to be greater than the benefits of fracture reduction, prevention of heart disease is not an approved indication for ERT. In short, many unanswered questions remain. [nap.edu]

• Arthritis

  Where to get help Arthritis The Arthritis Society (TAS) is the leading source of information on arthritis, including osteoarthritis. For more information about arthritis, contact: The Arthritis Society 1-800-321-1433 www.arthritis.ca. [osteoporosis.ca]

  Rheumatoid Arthritis (RA): A chronic disease that causes pain, swelling, redness, and irritation of the joints and changes in the muscles and bones. The condition can become more severe with time. Vertebrae: Bones of the spine. [acog.org]

  Introduction Osteoporosis is a common feature in adults with rheumatoid arthritis (RA), and may lead to an increased risk of fracture. [nras.org.uk]

  Others clinical manifestations, such as joint pain, arthritis, enthesopathy (calcification of ligaments and their attachment to bone), dentin malformation, and recurrent spontaneous abscesses of the teeth may occur with increasing age. [iofbonehealth.org]

  Other causes include: inflammatory arthritis (especially rheumatoid arthritis). inflammatory bowel disease coeliac disease chronic kidney disease. [yourhormones.info]

• Stroke

  For postmenopausal women, hormone replacement therapy is highly recommended except in women with a strong family history of breast cancer or a personal history of blood clots or stroke. [spine.keckmedicine.org]

  Breast cancer Gallbladder disease Blood clots High blood pressure (in some women) If you are using HT to prevent osteoporosis, be sure to talk to your doctor so that you can weigh the benefits of HT against your personal risk for heart attack, stroke, [my.clevelandclinic.org]

  Thromboembolic events (strokes, myocardial infarctions) are a significant risk at any age, especially so after age 20 years, and this is responsible for considerable morbidity and mortality. [disorders.eyes.arizona.edu]

  […] subtrochanteric fractures Conjugated Estrogen-progestin hormone replacement (HRT) in women with Type I (within 6 years of menopause) Decreased the risk of hip fracture, but it also led to small increases in a woman's risk of breast cancer, CAD and heart attack, stroke [orthobullets.com]

  However, due to adverse effects of HRT, such as increased risks of heart attack, stroke, blood clots in the veins, and breast cancer ; HRT is no longer recommended for long-term use in the therapy of osteoporosis. [medicinenet.com]

Screening at-risk populations is essential (see Workup). [emedicine.medscape.com]

Those not responding to treatment need evaluation and reassessment of treatment. [annals.org]

Your doctor takes this into account when they periodically review your treatment. If you've been taking your medication for five years or more Ask your doctor whether you need to stay on the treatment. [nos.org.uk]

"The number of patients receiving the treatment is quite low at present, but we are hoping this study will mean more prednisolone patients will receive the fracture-preventing treatment," he continues. [medicalxpress.com]

[…] those patients who would benefit from treatment versus those who actually are receiving it. [touchendocrinology.com]

Treatment Treatment Options: No effective treatment is known. [disorders.eyes.arizona.edu]

Prognosis is very variable depending on type ranging from being uniformly lethal from type II to a slight reduction in life expectancy for type I. [radiopaedia.org]

As part of her general monitoring, doctors took a bone density scan, which came back with her shocking prognosis. They think the two could be linked as her gastro-intestinal condition can result in the body not absorbing nutrients. [dailymail.co.uk]

This lower fracture risk was independent of BMD and other risk factors. [69] Prognosis The prognosis for osteoporosis is good if bone loss is detected in the early phases and proper intervention is undertaken. [emedicine.medscape.com]

What is the prognosis (outlook) for patients with osteoporosis? The outlook for patients with osteoporosis depends greatly on where fractures occur. Additionally, if treatment is begun when the bone disease is detected early, the outcome is better. [medicinenet.com]

Prognosis There is no cure for osteoporosis, but it can be controlled. Most people who have osteoporosis fare well once they receive treatment. The medicines available now build bone, protect against bone loss, and halt the progress of this disease. [medical-dictionary.thefreedictionary.com]

This variant was also associated with a risk of fracture among elderly heterozygous women that was two times as high as that among noncarriers, which indicates that genetic variation in PLS3 is a novel etiologic factor involved in common, multi-factorial [ncbi.nlm.nih.gov]

Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. {ECO:0000269 PubMed:24088043}. [genecards.org]

Furthermore, the discovery of a rare variant, associated with a twofold increased fracture risk in elderly females, indicates genetic variation in the identified candidate gene as a novel etiological factor involved in osteoporosis. [ashg.org]

Osteoporosis is a chronic condition of multifactorial etiology and is usually clinically silent until a fracture occurs. [uniprot.org]

[…] type MMEP syndrome Synonym(s): (no synonyms) Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare genetic disease Classification (ICD10): - Diseases of the musculoskeletal system and connective tissue - Epidemiological [csbg.cnb.csic.es]

Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences. Gastroenterology. 2004;126:1504-1517. Khalili H, Ananthakrishnan AN, Konijeti GG, et al. [crohnsdisease.com]

Department of Developmental Biology, University of Cologne, Cologne, Germany; 14 Department of Oral Cell Biology, ACTA, University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Amsterdam, the Netherlands; 15 Department of Epidemiology [bone-abstracts.org]

Department of Developmental Biology, University of Cologne, Cologne, Germany; 14) Department of Oral Cell Biology, ACTA, University of Amsterdam and VU University Amsterdam, MOVE Research Institute Amsterdam, Amsterdam, the Netherlands; 15) Department of Epidemiology [ashg.org]

Epidemiologic Studies The minor allele frequencies of the rs140121121 SNP in men and women, respectively, in the RS-I, RS-II, and RS-III cohorts were 0.022 and 0.016, 0.024 and 0.017, and 0.012 and 0.016. [nejm.org]

Evidence Rating Level: 2 (Good) Study Rundown: Osteoporosis is a multifactorial disease with a complex pathophysiology involving both genetic and environmental factors. [2minutemedicine.com]

This chapter summarizes present knowledge concerning the pathophysiology of osteoporosis and reviews evidence regarding the efficacy of potential interventions. [nap.edu]

Pathophysiology of atypical femoral fractures and osteonecrosis of the jaw. Osteoporos Int. 2011;22(12):2951–61. [PubMed] [Google Scholar] 32. Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, et al. [ncbi.nlm.nih.gov]

Pathophysiology It is increasingly being recognized that multiple pathogenetic mechanisms interact in the development of the osteoporotic state. [emedicine.medscape.com]

Prevention Certain alterations to lifestyle can reduce the risk of osteoporosis. Calcium and vitamin D Dairy produce is a good source of calcium and can help prevent osteoporosis. [medicalnewstoday.com]

The Second Fifty Years: Promoting Health and Preventing Disability. [nap.edu]

These drugs belong to a class of drugs called bisphosphonates, which prevent bone breakdown. They are used to prevent and treat osteoporosis. [my.clevelandclinic.org]

SERMs seem to prevent bone loss in your spine, hip, and throughout your body. Raloxifene is the SERM drug currently approved by the FDA for prevention of osteoporosis. [depuysynthes.com]