Xanthelasma palpebrarum lesions are benign but present cosmetic problems to the patient. Their surgical removal has also presented problems to the surgeon. [ncbi.nlm.nih.gov]

Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 11 Review Video abstract presented by Pragya A Nair. [doi.org]

• Laboratory Technician

  Xanthelasmata and arcus corneae Trained nurses or medical laboratory technicians, who were unaware of the participants’ risk and disease profile, determined the presence of xanthelasmata and arcus corneae by careful visual inspection of the eyelids and [ncbi.nlm.nih.gov]

• Medical Laboratory Technician

  Xanthelasmata and arcus corneae Trained nurses or medical laboratory technicians, who were unaware of the participants’ risk and disease profile, determined the presence of xanthelasmata and arcus corneae by careful visual inspection of the eyelids and [ncbi.nlm.nih.gov]

• Koebner Phenomenon

  We find no report of Koebner phenomenon in xanthelasma palpebrarum in the English literature, but there are a few case reports of Koebner phenomenon in eruptive xanthoma [8, 9] and in diffuse palmar xanthoma [10]. [escholarship.org]

  Koebner phenomenon in xanthelasma after treatment with trichloroacetic acid. Dermatol Online J. 2006;12(2):12. 26. Dewan SP, Kaur A, Gupta RK. Effectiveness of cryosurgery in xanthelasma palpebrarum. [dovepress.com]

• Lagophthalmos

  In some very rare instances abnormally large xanthelasma can interfere with proper eyelid function causing a droopy lid (ptosis) or incomplete lid closure (lagophthalmos). [kanataoptometry.ca]

  Recurrent xanthelasma bilateral upper lids; previous excision combined with blepharoplasty; patient insistent on repeat excision and blepharoplasty; advised of lagophthalmos risk due to medial position and lack of medial dermatochalasis. [emedicine.com]

• Transient Blindness

  The diagnostic criteria for ischaemic cerebrovascular disease were ischaemic stroke, transient ischaemic attack (focal neurological symptoms lasting less than 24 hours), or amaurosis fugax (transient blindness in one eye only). [ncbi.nlm.nih.gov]

Because of the present confusion as to whether normolipidemic patients with xanthelasma have an increased risk of carotid atherosclerosis, I wrote to her primary-care clinician regarding the patient’s possible need for cardiac workup. [clinicaladvisor.com]

At that time, the patient was referred to her primary care physician to undergo workup for dyslipidemia. [jamanetwork.com]

What workup is required for xanthoma? A skin biopsy may be necessary to confirm a clinical diagnosis of xanthoma. See eruptive xanthoma pathology. [dermnetnz.org]

• Hypochlorhydria

  The patient was a 75-year-old Hispanic woman with atrophic fundic (oxyntic) gland gastritis leading to hypochlorhydria, secondary hypergastrinemia, endocrine cell hyperplasia, and multiple gastric carcinoids. [ncbi.nlm.nih.gov]

However, local anesthesia is always required, and there is a concrete risk of scarring and pigmentation changes after the treatment. In this case report, we describe for the first time the treatment of xanthelasmas with the pulsed dye laser. [ncbi.nlm.nih.gov]

Other options include surgical excision, laser treatment, local application of a special acid solution and electrodesiccation (electric needle treatment). [dermapics.com]

Different modalities of treatment, such as simple surgical excision, cryotherapy, chemical peeling with trichloroacetic acid, radiofrequency, and laser, are used in the treatment of xanthelasma palpebrarum. [doi.org]

Prognosis The condition itself is harmless. The prognosis depends on any association with underlying lipid abnormalities and cardiovascular risk. [patient.info]

Prognosis[edit] Recurrence is common: 40% of patients with XP had recurrence after primary surgical excision, 60% after secondary excision, and 80% when all four eyelids were involved. [en.wikipedia.org]

A diagnosis of xanthelasma palpebrarum was made, and she was counseled regarding the prognosis of the disease that the lesions do not have any chances of turning cancerous. Figure 1 (a) Yellowish plaque involving the four eyelids. [ijsronline.net]

Natural History, Complications, Prognosis The lesions themselves are not harmful or painful. They may, however, be a marker of underlying atherosclerosis [3]. [wikidoc.org]

Prognosis Recurrence is common. Patients need to be aware that studies completed after surgical excision showed recurrence in up to 40% of patients. This percentage is higher with secondary excisions. [emedicine.com]

Epidemiology Rare; Accounting for 32% in women and 17.4% in men in the United States Etiology Elevated plasma lipid levels Pathogenesis Localized collection of tissue histiocytes or macrophages containing lipid Clinical Soft yellow plaques over eyelids [dermpathdiagnostics.com]

Etiology Pathophysiology There is good evidence that the lipid found within xanthomas is the same lipid circulating in high concentrations in the plasma of patients. However, the exact mechanisms that induce xanthoma formation are less clear. [dermatologyadvisor.com]

No etiological agent could be identified. Post polypectomy, there was no recurrence or detection of carcinoma in stomach at the end of the 6-month follow up period. [tropicalgastro.com]

Etiology About 50% of patients who develop xanthelasma have lipid disorder. [statpearls.com]

Epidemiology Rare; Accounting for 32% in women and 17.4% in men in the United States Etiology Elevated plasma lipid levels Pathogenesis Localized collection of tissue histiocytes or macrophages containing lipid Clinical Soft yellow plaques over eyelids [dermpathdiagnostics.com]

A possible cause might be insufficiently deep excisions.[2] Epidemiology[edit] Xanthelasma is a rare disorder in the general population, with a variable incidence of 0.56–1.5% in western developed countries. [en.wikipedia.org]

Mette Christoffersen and Anne Tybjærg-Hansen, Visible aging signs as risk markers for ischemic heart disease: Epidemiology, pathogenesis and clinical implications, Ageing Research Reviews, 10.1016/j.arr.2015.11.002, 25, (24-41), (2016). [doi.org]

Keywords: eyelid • tumors • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled clinical trials 2007, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. [iovs.arvojournals.org]

Xanthelasma are distinct from xanthoma which are larger and nodular, lesions. [1] Xanthelasma are sometimes classified as a subtype of xanthoma. [2] Epidemiology and Demographics A study of 12,745 people from Denmark identified xanthelasmata in 4.4% of [wikidoc.org]

They represent areas of lipid-containing macrophages but the exact pathophysiology is not known. In other areas of the body the individual lesion would be called a xanthoma; xanthelasma is the most common xanthoma[1]. By Klaus D. [patient.info]

Clinical, cosmetic and investigational dermatology. 2018; [PubMed PMID: 29296091] [5] Zak A,Zeman M,Slaby A,Vecka M, Xanthomas: clinical and pathophysiological relations. [statpearls.com]

While the pathophysiology of this condition is not clearly understood, lesions are commonly seen in those with hyperlipidemia. [jkslms.or.kr]

The age of onset ranges from 20 to 70 years, but it is most commonly seen between the age of 35 and 55 years.[5][6] Pathophysiology Xanthelasmas are the most widely recognized type of xanthoma. [ncbi.nlm.nih.gov]

Although xanthelasma themselves are often asymptomatic, investigations into and treatment of any underlying cause(s) are warranted to prevent morbidity from lipid disorders and to prevent xanthelasma from progressing. [visualdx.com]

Having either a significant lipoprotein abnormality and/or coronary plaque identified by a heart scan should then prompt an intensified effort to prevent the heart attack that is likely in future without proper preventive action. [healthcentral.com]

The treatments may cause minor scarring and does not prevent new lesions from forming. [dermpathdiagnostics.com]

The area to be treated is first numbed with a local anaesthetic solution to prevent any discomfort associated with the treatment. Radio-wave, Erbium or Carbon dioxide laser is then used to ablate (evaporate) the xanthelasma down to skin level. [medaesthetics.com.au]