Most cases presented papillary epithelial hyperplasia and sub-epithelial foamy cells, which were immunopositive for CD68, CD63 and CD163 in all cases. [ncbi.nlm.nih.gov]

The case is presented to emphasize the importance of considering the disease entity even in patients with normal lipid profile. Case Presentation A 69 year old male presented with asymptomatic lesions over hands, foot, nose and ears since 2 months. [austinpublishinggroup.com]

• Pain

  Epigastric pain was dull, intermittent, nonradiating with no specific aggravating factors and relieved with pain medications and antacids. He did not have chest pain, fever or diarrhea, or urinary symptoms. He never had similar symptoms in the past. [journals.lww.com]

  Typically, they are neither painful nor harmful. Although they are fatty deposits, the presence of a xanthelasma does not necessarily indicate that one has high cholesterol. [aao.org]

  He denied having fever, chills, myalgia, abdominal pain, visual changes, recent changes in medications, or contact with anyone with similar symptoms. [mdedge.com]

  The pain was often greater after overactivity and was relieved after rest with no obvious nocturnal pain. [journals.sagepub.com]

  A 10-year-old non-obese boy presented with a painful nodular eruptions over the back of ankles for the last 5 years. [ncbi.nlm.nih.gov]

• Weakness

  The KP1 and Mac 387 immunostain showed focal weak staining in foam cells. [insights.ovid.com]

  [yellow copper ore; brass]. palleo -ere [to be pale or yellow]; partic. pallens -entis, [pale, wan, yellow, pale green; causing paleness; drooping, weak]. pallesco pallescere pallui [to grow pale or yellow]; with acc., [to turn pale at]. [arkisto.kaijuli.fi]

  In February 1995 she developed dyspnoea, wheeze, and a weak voice. Examination at that time revealed a fixed wheeze in the left lung and slight hoarseness of the voice. [thorax.bmj.com]

  […] amongst, within) अंतर्राष्ट्रीय (antarrāṣtrīya) = international अंश- (amsh-) Sanskrit अंश (part, portion) अंशकालिक (amśakālik) = part-time; अंशांकन (amśānkan) = calibration क (k)[] कम- (kam-) min- Persian کم (kam) (low, little, small) कमज़ोर (kamzor) = weak [en.wikibedia.ru]

  […] internal, amongst, within) अंतर्राष्ट्रीय (antarrāṣtrīya) = international अंश- (amsh-) Sanskrit अंश (part, portion) अंशकालिक (amśakālik) = part-time; अंशांकन (amśānkan) = calibration कम- (kam-) min- Persian کم (kam) (low, little, small) कमज़ोर (kamzor) = weak [akaarstar.wordpress.com]

• Turkish

  Author(s): Priya Kamath | Vittalrao Dhulked | Mahadeva Dixit | Mrityunjay Metgud Journal: Journal of the Turkish-German Gynecological Association ISSN 1309-0399 Volume: 09; Issue: 01; Start page: 52; Date: 2008; VIEW PDF DOWNLOAD PDF Original page Keywords [journaldatabase.info]

  Ziyal, “Bilateral temporal bone xanthomas in type II hypercholesterolemia,” Turkish Neurosurgery, vol. 20, no. 4, pp. 533–535, 2010. View at: Google Scholar K. A. Muthusamy, K. Azmi, P. Narayanan, R. Rajagopalan, N. A. Rahman, and V. [hindawi.com]

  Romanian - Vietnamese xanthomata 80 millions of speakers Translator Romanian - Tamil xanthoma 75 millions of speakers Translator Romanian - Marathi त्वचेखाली स्निग्ध पदार्थ जमल्यामुळे त्वचेवर विवळे डाग पडणे 75 millions of speakers Translator Romanian - Turkish [educalingo.com]

• Vietnamese

  German Xanthome 180 millions of speakers Translator Romanian - Japanese 黄色腫 130 millions of speakers Translator Romanian - Korean xanthomata 85 millions of speakers Translator Romanian - Javanese xanthoma 85 millions of speakers Translator Romanian - Vietnamese [educalingo.com]

• Fatigue

  A 67-year-old man presented with dyspnea, general fatigue, and leg edema. Echocardiography demonstrated a large pericardial effusion with a 5 cm × 3 cm, dense hetero-echogenic tumor in the right atrium. [ncbi.nlm.nih.gov]

  Some sleep problems can lead to serious health issues such as heart attack, stroke, high blood pressure, fatigue-related motor vehicle accidents, and decreased quality of life. [excelahealth.org]

• Abdominal Pain

  He denied having fever, chills, myalgia, abdominal pain, visual changes, recent changes in medications, or contact with anyone with similar symptoms. [mdedge.com]

  Advanced Search: • Use “ “ for phrases o [ “pediatric abdominal pain” ] • Use – to remove results with certain terms o [ “abdominal pain” –pediatric ] • Use OR to account for alternate terms o [teenager OR adolescent ] [msdmanuals.com]

  Image Article An otherwise healthy 35 years old female not known to be diabetic presented to the outpatient clinic complaining of itchy papular generalized skin eruption, afebrile, no chest or abdominal pain ( Figure 1 ). [medical-clinical-reviews.imedpub.com]

• Nausea

  Case description An 18-year-old Hispanic female with a history of poorly controlled type I diabetes mellitus for 7 years was brought to the emergency department, complaining of nausea, dizziness, and skin lesions. [tandfonline.com]

  […] multiple yellowish, erythematous papules on the extremities suggestive of eruptive xanthomas admitted to our hospital with diabetic ketoacidosis. 2 Case presentation We present a case of 44-year-old man who presented to the emergency department with nausea [journals.lww.com]

• Vomiting

  A 32-year-old human immunodeficiency virus-positive male was admitted for headache and vomiting. He was diagnosed with meningitis due to Cryptococcus neoformans and sputum tested positive for Pneumocystis. [ncbi.nlm.nih.gov]

  […] yellowish, erythematous papules on the extremities suggestive of eruptive xanthomas admitted to our hospital with diabetic ketoacidosis. 2 Case presentation We present a case of 44-year-old man who presented to the emergency department with nausea, vomiting [journals.lww.com]

• Heart Disease

  Session Title: Managing Patients With Stable Ischemic Heart Disease: A Multitude of Things to Consider Abstract Category: 02. [onlinejacc.org]

  Heart, 76(1): 84-5 [ CR ] [ PM ] [ EČ ][ GS ] Richter, W.O., Donner, M.G., Höfling, B., Schwandt, P. (1998) Long-term effect of low-density lipoprotein apheresis on plasma lipoproteins and coronary heart disease in native vessels and coronary bypass in [scindeks.ceon.rs]

  It may be associated with raised blood cholesterol, high-density lipoprotein and triglyceride levels, leading to heart disease or diabetes. Syn. xanthoma; xanthelasma palpebrarum; xanthoma palpebrarum. See corneal arcus ; Hollenhorst's plaque. [medical-dictionary.thefreedictionary.com]

  The risk of cardiovascular disease, including heart attacks, peripheral vascular disease and stroke, is increased with elevated levels of certain lipoproteins. [dermnetnz.org]

• Xanthoma

  (also known as tuberous xanthoma) is characterized by xanthomas located over the joints.[2]:530 Xanthoma tendinosum[edit] Xanthoma tendinosum (also tendon xanthoma or tendinous xanthoma[5]) is clinically characterized by papules and nodules found in [en.wikipedia.org]

  The features of a man with a scrotal verruciform xanthoma are presented. Using PubMed, the following terms were searched and relevant citations assessed: anogenital, foam cells, penis, scrotum, verruciform, verruciform xanthoma, vulva, and xanthoma. [ncbi.nlm.nih.gov]

  and verruciform xanthoma. [emedicine.com]

• Eruptions

  Eruptive xanthomas are benign skin lesions caused by localized deposition of lipids in the dermis. [ncbi.nlm.nih.gov]

  Eruptive xanthoma. Ann Emerg Med 2013; 61:595603. 7. Zaremba J, Zaczkiewicz A, Placek W. Eruptive xanthomas. Postepy Dermatol Alergol 2013; 30:399–402. 8. Naik NS. Eruptive xanthomas. Dermatol Online J 2001; 7:11. 9. [journals.lww.com]

  [Table 1][2] Clinically, xanthomas can be classified as eruptive, tubero –eruptive or tuberous, tendinous or planar. [jihs.in]

  […] xanthomata.[5] Other types[edit] Other types of xanthoma identified in the Medical Dictionary include:[8] Xanthoma diabeticorum: a type of eruptive xanthoma, often with severe diabetes. [en.wikipedia.org]

• Xanthelasma

  Mixed hyperlipidemia due to type 1 diabetes mellitus Mixed hyperlipidemia due to type 2 diabetes mellitus R lower xanthelasma R upper xanthelasma R xanthelasma Right lower xanthelasma Right upper xanthelasma Right xanthelasma Tuberous xanthoma Xanthelasma [icd9data.com]

  Types[edit] Xanthelasma[edit] Histology picture of xanthoma showing lipid-laden foam cells with large areas of cholesterol clefts, 10 × magnification, eosin and hematoxylin stain[1] A xanthelasma is a sharply demarcated yellowish collection of cholesterol [en.wikipedia.org]

  Figure 4 Figure 5 Patient following treatment of xanthelasma and papular xanthoms Discussion We present a rare case of normolipemic papular xanthoma with xanthelasma in a young female. [escholarship.org]

  xanthelasma, treatment of xanthelasma, treatment for xanthelasma, xanthelasma treatments, treatment xanthelasma, xanthelasma treatment, removing xanthelasma at home, xanthelasma removal at home, xanthelasma home removal, xanthelasma of eyelid, eye xanthelasma [xanthel.com]

• Skin Disease

  We report a case of a solitary verruciform xanthoma on the forearm of an 82-year-old man without history of chronic dystrophic skin disease or syndrome. [ncbi.nlm.nih.gov]

  […] of the skin, skin disease, skin disorder a disease affecting the skin [vocabulary.com]

  Text Reference: Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional, and Deposition Disease, 1st edition: "Dyslipidemia (Hyperlipidemia)" [emedicinehealth.com]

  Treatment of Skin Disease: Comprehensive Therapeutic Strategies. 4th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 248. Updated by: David L. [nlm.nih.gov]

  […] and CONNECTIVE TISSUE DISEASES CONNECTIVE TISSUE DISORDERS HUIDKLACHTEN HUIDZIEKTEN SKIN NEOPLASMS SKIN ULCER SKIN DISEASES DERMATOHELIOSIS SYSTEMIC SKIN DISEASES Zie ook: OOGAANDOENINGEN OOGAFWIJKINGEN OOGKLACHTEN OOGZIEKTEN OOGHEELKUNDE EYE DISEASES [catsclem.nl]

• Pruritus

  Clinical manifestation varies from asymptomatic skin lesions to intense pruritus and tenderness. We present a case of a middle-aged man admitted with diabetic ketoacidosis secondary to noncompliance with insulin. [ncbi.nlm.nih.gov]

  The triad of pruritus, xanthomas, and cholestasis: Two cases and a brief review of the literature. Pediatr Dermatol. 2017 Nov. 34 (6):e305-e308. [Medline]. Giller RH, Folberg R, Keech RV, Piette WW, Sato Y. Xanthoma disseminatum. [emedicine.medscape.com]

  Pruritus is common and lesions may become tender. Eruptive xanthomas often indicate severe hypertriglyceridemia and uncontrolled diabetes mellitus [ 2 Hegele RA, Ginsberg HN, Chapman MJ, et al. [tandfonline.com]

  Acutely, variable amounts of pruritus and pain can occur. In this case however patent did not report any symptoms related to the skin lesions. [journals.lww.com]

• Fear

  [xeno- + G. phobos, fear] xenophonia (zen-o-fo′ne-a) A speech defect marked by an alteration in accent and intonation. [theodora.com]

  […] bāṣpātu) = rhenium बे- (be-) Persian بی (be) (without) बेतार (betār) = wireless; बेशुमार (beshumār) = uncountable, innumerable -बीन (-bīn) -scope दूरबीन (dūrbīn) = binoculars; खुर्दबीन (khurdbīn) = microscope भ (bh)[] भीति- (bhīti-) phobia- Sanskrit भीति (fear [en.wikibedia.ru]

  बाष्पातु (bāṣpātu) = rhenium बे- (be-) Persian بی (be) (without) बेतार (betār) = wireless; बेशुमार (beshumār) = uncountable, innumerable -बीन (-bīn) -scope दूरबीन (dūrbīn) = binoculars; खुर्दबीन (khurdbīn) = microscope भीति- (bhīti-) phobia- Sanskrit भीति (fear [akaarstar.wordpress.com]

  He was armed with a wooden ladle and ahu with a heavy frrlng-pan, and they were belaboring each other nnmerclfullr, "The fact le.lther were about eren-If matched, bnt I did not hare time to Me this, and fearing tho women would b hurt. [newspapers.com]

  […] bāṣpātu) = rhenium बे- (be-) Persian بی (be) (without) बेतार (betār) = wireless; बेशुमार (beshumār) = uncountable, innumerable -बीन (-bīn) -scope दूरबीन (dūrbīn) = binoculars; खुर्दबीन (khurdbīn) = microscope भ (bh) भीति- (bhīti-) phobia- Sanskrit भीति (fear [wikimili.com]

• Irritability

  Patients presented either incidentally or with microscopic haematuria or irritative symptoms. Patients with isolated xanthomas had a mean age of 65.3 years (range: 54-75 years) and an equal male to female ratio. [ncbi.nlm.nih.gov]

  She then complained of bright orange colored nodules on the palms of her hands, on the elbows, feet, knees and other areas of the skin which were frequently irritated by friction. [annals.org]

  Chauffard (10) and Pollitzer and Wile (2) conclude that xanthoma tuberosum represents an irritation connective-tissue hyperplasia in which the extravasation of cholesterol fatty-acid esters, present in excess in the blood, serves as a stimulant. [cancerres.aacrjournals.org]

  It can be because of the damage to the squamous cells due to trauma, irritation, or infection, which can cause increased epithelial turnover leading to the disease. [hindawi.com]

  This fact is most relevant, since in the case reported, the patient made use of an orthodontic appliance, and this is a possible local irritant that may cause appearance of the lesion. [scielo.br]

• Confusion

  […] xanthoma presenting as peripherally enhancing mass in the patient with xanthoma disseminatum, which was a histiocytic disorder occurring in the absence of hyperlipidemia and hypercholesterolemia.5 Because of the rarity of this condition, considerable confusion [ajnr.org]

  Discussion The Achilles tendon is commonly the location of tendinous xanthoma, in addition to tendons of the hand (extensor tendons) and those of the elbow.1,2 It is rarely observed in clinical practice and can easily be confused with neurofibromatosis [journals.sagepub.com]

  Daṇḍin acknowledged that there are words and confusing structures in Prakrit that thrive independent of Sanskrit. [wikivisually.com]

  Gastric Xanthoma must not be confused with accumulation of lipid, submucosal lipoma, pseudolipomatosis, or accumulation of histiocytes without a visible lesion ( 35 ). 3.6. Treatment There are no recommendations for the treatment of GX. [emedicalj.com]

• Seizure

  The patient was a 51-year-old woman with headaches and absence seizures. Axial T1-weighted MRI showed a well-demarcated, hypointense, osteolytic, 25 × 18 × 15 mm lesion with cortical erosion located at the right margin of the clivus. [ncbi.nlm.nih.gov]

  An obese 50-year-old man with hypertension, hyperlipidemia, recently diagnosed diabetes, and a history of grand mal seizures presented to the emergency room complaining of skin rash for 1 week. [mdedge.com]

  Meningeal involvement is common and occur in the form of diabetes insipidus (40% of cases), seizures and growth retardation. HPE shows scalloped macrophages. References 1. Winkelmann RK. Adult histiocytic skin diseases. [ijpd.in]

  [xantho + astrocytoma] pleomorphic x. a rare variant of astrocytoma usually presenting early in life with seizures. The tumor is superficially located and composed of pleomorphic glial cells, lipidized astrocytes, and perivascular lymphocytes. [theodora.com]

• Insomnia

  INSOMNIA AS PROFESSION. Vow Jersey Xan Tama Hie Inability (a Sleep Into a Source of Id co ma. When ynn lay tn four doctor: "I haven't alept wink tor 41 houra," ht probably emllce faintly and eympathet' Ically. [newspapers.com]

This study reports the case of a 60-year-old man having painless nodules on his elbows and Achilles tendons without typical gout crisis, followed in the microcrystalline disease clinic of Unifesp for diagnostic workup. [scielo.br]

A thorough workup is essential to identify the underlying condition in order to initiate early treatment and to prevent later complications. [austinpublishinggroup.com]

[…] pancreatitis is 5%, and at levels above 2,000 mg/dL, the risk is 10% to 20%. 4 In our patient, the diagnosis of chylomicronemia was based on the appearance of the skin lesions, his history of pancreatitis and diabetes mellitus, and the results of the initial workup [mdedge.com]

This study reports the case of a 60-year-old man having painless nodules on his elbows and Achilles tendons without typical goutcrisis, followed in the microcrystalline disease clinic of Unifesp for diagnostic workup. [mendeley.com]

References: [4] [1] [14] [15] Diagnostics Laboratory analysis Fasting lipid profile : total cholesterol, HDL, and triglycerides are measured Identify underlying cause Fasting blood glucose level or Hb1Ac TSH level Liver function tests Urine analysis Further workup [amboss.com]

• Dyslipidemia

  CONCLUSION: Thorough familiarity with the clinical presentation of xanthomas helps in the diagnosis and follow-up of different forms of dyslipidemia. [ncbi.nlm.nih.gov]

  Text Reference: Clinical and Pathological Aspects of Skin Diseases in Endocrine, Metabolic, Nutritional, and Deposition Disease, 1st edition: "Dyslipidemia (Hyperlipidemia)" [emedicinehealth.com]

  […] lipoprotein present in excess (working classification of dyslipidemias). [jihs.in]

Early recognition and treatment of the underlying condition decreases morbidity and mortality. After treatment of the underlying metabolic disorders, lesions mostly disappear without leaving scars. [ncbi.nlm.nih.gov]

References ↵ ↵ ↵ National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). [cmaj.ca]

[…] of xanthelasma, treatment for xanthelasma, xanthelasma treatments, treatment xanthelasma, xanthelasma treatment, removing xanthelasma at home, xanthelasma removal at home, xanthelasma home removal, xanthelasma of eyelid, eye xanthelasma, eyelid xanthelasma [xanthel.com]

Early diagnosis and treatment of this disease with chenodeoxycholic acid is essential and has been shown to greatly improve the patient's symptoms and prognosis. [ncbi.nlm.nih.gov]

Prognosis The prognosis is good after treatment of bone xanthoma [1,4-6,8,9,11]. [omicsonline.org]

Outlook (Prognosis) The growth is non-cancerous and painless, but may be a sign of another medical condition. When to Contact a Medical Professional Call your health care provider if xanthomas develop. [indiatoday.in]

Outlook (Prognosis) The growth is noncancerous and painless, but may be a sign of another medical condition. When to Contact a Medical Professional Call your provider if xanthomas develop. [ufhealth.org]

Outlook (Prognosis) The growth is noncancerous and painless, but may be a sign of another medical condition. Prevention Control of blood lipids, including triglycerides and cholesterol levels, may help reduce development of xanthomas. [account.allinahealth.org]

Verruciform xanthoma (VX) is an uncommon mucocutaneous lesion of uncertain etiology. Originally thought to be limited to the oral mucosa, its occurrence in other mucosal and nonmucosal sites also has been documented. [ncbi.nlm.nih.gov]

American Journal of Surgical Pathology. 22(4):479-487, APRIL 1998 PMID: 9537477 Issn Print: 0147-5185 Publication Date: April 1998 Checking for direct PDF access through Ovid Abstract Verruciform xanthoma is a rare clinicopathologic entity of uncertain etiology [insights.ovid.com]

Multiple myeloma and histiocytosis X are less common etiologies. The patient pictured here has biliary cirrhosis. Source: Color Atlas of Pediatric Dermatology Samuel Weinberg, Neil S. [medicinenet.com]

References: [1] [2] Epidemiology References: [2] Epidemiological data refers to the US, unless otherwise specified. [amboss.com]

Summary Epidemiology The incidence of WAS has been estimated at less than 1 in 100,000 live births. The disease almost exclusively affects males. [orpha.net]

[…] flat xanthomas, verrucous xanthomas, and xanthelasma.[1] Eruptive xanthoma most commonly involves the extensor surfaces of the extremities, buttocks, and back.[2] The disease is a characteristic manifestation of extreme hypertriglyceridemia.[3] Exact epidemiological [journals.lww.com]

Epidemiology The reported incidence of GX was quite variable: it ranged from 0.018% to 7% in endoscopy series and was as high as 58% in an autopsy series ( 3 - 6 ). [emedicalj.com]

Xanthomas: clinical and pathophysiological relations. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014 ;158: 181 – 188. [Crossref], [Web of Science ®], [Google Scholar] ]. [tandfonline.com]

We discuss the clinical features, pathophysiology and treatment of CTX. As the condition is treatable, this is a neurological rarity not to be missed. [pn.bmj.com]

Etiology Classification Pathophysiology Clinical features Typically no specific signs or symptoms Skin manifestations Xanthoma : nodular lipid deposits in the skin and tendons Pathophysiology: Extremely high levels of triglycerides and/or LDL result in [amboss.com]

The pathophysiology relates to structural mutation with defective actin polymerization in hematopoietic cells as a result of deficient or dysregulated activity of the Wiskott-Aldrich syndrome protein (WASp) which has multiple functions. [radiopaedia.org]

Prompt recognition of such skin manifestations is warranted to prevent development of fatal medical condition like coronary artery disease and pancreatitis. [ncbi.nlm.nih.gov]

In either case, a child with tendinous xanthomas requires prompt evaluation and medical treatment to prevent irreversible disease sequelae. [visualdx.com]

Prevention Keeping your blood lipids within a normal range through healthy eating and maintaining a healthy weight can help. [healthnavigator.org.nz]

Sources: National Diabetes Information Clearinghouse: “Prevent diabetes problems: Keep your feet and skin healthy.“ American Diabetes Association: “Skin Complications.” [webmd.com]