The gross and microscopic pathology are presented with immunohistochemical, ultrastructural and biochemical details. [ncbi.nlm.nih.gov]

To the best of our knowledge, the present report is the only one that characterizes XD on a molecular level. [medicaljournals.se]

• Galactorrhea

  A 23-year-old woman presented with a 9-month history of polydipsia, polyuria, galactorrhea, secondary amenorrhea, and weight gain. Her previous medical history included chronic anemia and widespread mucocutaneous xanthomas. [ncbi.nlm.nih.gov]

  Results: A 23-year-old woman presented with a 9-month history of polydipsia, polyuria, galactorrhea, secondary amenorrhea, and weight gain. Her previous medical history included chronic anemia and widespread mucocutaneous xanthomas. [journals.aace.com]

• Inguinal Lesions

  The underarm lesions and inguinal lesions had improved significantly. He had no new lesions develop during follow-up. After 6 months of follow-up, the lesions continued to flatten, with involution of the XD lesions and no evidence of new lesions. [jamanetwork.com]

• Axillary Lesion

  Axillary lesions of the patient in case 7 after 5 cycles of treatment with 2-chlorodeoxyadenosine. A, Right side; B, left side. [jamanetwork.com]

• Euthyroid

  […] non-Langerhans cell histiocytosis that manifests clinically as discrete reddish-brown or reddish-yellow, xanthoma-like papules and nodules involving the face, body flexures, oropharyngeal, laryngeal, conjunctival, and corneal mucosae in a normolipemic and euthyroid [ijdvl.com]

• Limb Pain

  The patient never complained of limb pains, and skeleton X-ray examinations requested for other studies found no bone abnormality. [karger.com]

• Hoarseness

  Skin lesions were accompanied by blurred vision and hoarseness of voice. Examination revealed xanthomatous infiltration of cornea, oral, pharyngeal, and laryngeal mucosae. [ncbi.nlm.nih.gov]

  Patients present with characteristic mucocutaneous lesions, diabetes insipidus, dysphagia, dyspnea, hoarseness of voice, and blurred vision. [orpha.net]

  Liu Y. 2018 2 A case of xanthoma disseminatum treated with imatinib mesylate. ( 28401671 ) Sawatkar G.U....Dogra S. 2017 3 Dermatoscopic features of xanthoma disseminatum. ( 28940376 ) Vinay K....Dogra S. 2017 4 Xanthoma Disseminatum Presenting with Hoarseness [malacards.org]

  There was no history of seizures, dysphagia, dyspnea, hoarseness of voice, blindness, increased urinary frequency, bone pain or any gastrointestinal complaints. Family history was non-contributory. [e-ijd.org]

• Sore Throat

  He had a sore throat and severe hoarseness of his voice. There was also infiltration of the pituitary stalk, adenoids, and soft palate. The patient's lipid profile results showed a high triglyceride level. [jamanetwork.com]

• Lesion of the Tongue

  Involvement of eyelids, when severe, hinders the blinking and obscure visual field. [1] Mucosal lesions of gums, tongue, oropharynx, larynx, epiglottis, trachea, and bronchi occur in 50% cases and often cause dysphagia or dyspnoea at times requiring tracheostomy [ijdvl.com]

• Shoulder Pain

  【肩関節周囲炎】*scapulohumeral periarthritis 【肩甲骨痛】*scapulalgia *scapulodynia 【肩脱臼】*shoulder dislocation 【肩痛】*shoulder pain *omalgia *omodynia 【剣状突起炎】*xiphoiditis 【剣状突起結合体】*xiphopagus 【顕性遠視】*manifest hyperopia (略 Hm) (コ) 【コイロサイトーシス】*koilocytosis (＝空胞細胞症) 【コクシジウム [medo.jp]

• Diplopia

  The patient suffered from diplopia and had a severe sensorimotor polyneuropathy causing progressive paresis of the limbs. [ncbi.nlm.nih.gov]

  […] subluxation 【不全対麻痺】*paraparesis 【不全麻痺】*paresis 【不耐性】*intolerance 【不定疼痛】*atypical pain 【不眠症】*insomnia *agrypnia (浮) 【浮腫】*edema (＝水腫) (婦) 【婦人病】*gynecopathy *gynopathy *female complaint (付) 【付属器炎】*adnexitis ＝子宮付属器炎 (風) 【風疹】*rubella *German measles (複) 【複視】*diplopia [medo.jp]

• Corneal Infiltrate

  Ocular examination revealed conjunctival and left corneal infiltration by yellow minute papules with normal visual field. Abdomino-pelvic ultrasonography, chest X-ray, upper and lower gastrointestinal endoscopy revealed no abnormality. [jpgmonline.com]

• Night Sweats

  A 10-year-old boy was admitted to the University Hospital complaining of exhaustion, night sweats, coughing and dyspnea. Physical examination, laboratory findings and histopathological examination led to the diagnosis of Xanthoma disseminatum. [ncbi.nlm.nih.gov]

  Adverse effects of 2-CdA were limited to joint pain and night sweats. After 5 treatment cycles, the patient had no new lesions and had achieved additional improvement in established lesions, which were more flat and less erythematous. [jamanetwork.com]

• Facial Skin Lesion

  Treatment was initiated with cabergoline, nasally administered desmopressin, radio-frequency ablation of facial skin lesions, and surgical excision of other accessible lesions. [ncbi.nlm.nih.gov]

• Self-Inflicted Wound

  The patient refused any systemic treatment and later died of self-inflicted wounds. Figure 3. [jamanetwork.com]

• Paresis

  The patient suffered from diplopia and had a severe sensorimotor polyneuropathy causing progressive paresis of the limbs. [ncbi.nlm.nih.gov]

  RA) 【不可避流産】*inevitable abortion 【不完全ブロック】*partial block 【不整脈】*cardiac arrhythmia/*arrhythmia 【不全感染】【不発感染】*abortive infection (＝頓挫感染) 【不全症】*insufficiency 【不全整復】*malreduction 【不全脱臼】*incomplete dislocation *[＝亜脱臼] subluxation 【不全対麻痺】*paraparesis 【不全麻痺】*paresis [medo.jp]

• Dysarthria

  The patient’s facial droop, dysarthria, and nausea and vomiting improved, but she remained weak on the left side of her body. Within the first week after biopsy, notable thrombocytopenia developed; this also improved. [ajnr.org]

• Secondary Amenorrhea

  A 23-year-old woman presented with a 9-month history of polydipsia, polyuria, galactorrhea, secondary amenorrhea, and weight gain. Her previous medical history included chronic anemia and widespread mucocutaneous xanthomas. [ncbi.nlm.nih.gov]

  Results: A 23-year-old woman presented with a 9-month history of polydipsia, polyuria, galactorrhea, secondary amenorrhea, and weight gain. Her previous medical history included chronic anemia and widespread mucocutaneous xanthomas. [journals.aace.com]

Progress logically from the histologic pattern, through the appropriate workup, around the pitfalls, to the best diagnosis. [books.google.it]

A thorough workup is essential to identify the underlying condition in order to initiate early treatment and to prevent later complications. [austinpublishinggroup.com]

The macroscopic lesions arise from phagocytosis in the dermis of plasma lipoproteins that leak from capillaries. 1 Laboratory workup is mandatory to exclude diabetes, nephrotic syndrome, or hypothyroidism. [hkmj.org]

Systemic examinations including oropharyngeal, ophthalmic, and otorhinolaryngological workup, and laboratory investigations including blood counts, serum biochemistry, thyroid function tests, lipidprofile, urinalysis, ECG, chest X-ray, and ultrasonographic [ijdvl.com]

• Atelectasis

  Chest x-rays showed hyperaeration and segmental atelectasis. High-resolution CT of the thorax revealed diffuse thickening of the whole tracheal and bronchial wall, and bronchiectasis in the lower lobes. [ncbi.nlm.nih.gov]

  Chest x‐rays showed hyperaeration and segmental atelectasis. High‐resolution CT of the thorax revealed diffuse thickening of the whole tracheal and bronchial wall, and bronchiectasis in the lower lobes. [doi.org]

  【象牙質腫】*dentinoma (増) 【増殖型網膜症】*proliferating retinopathy 【増殖性糸球体腎炎】*proliferative glomerulonephritis 【増殖性心内膜炎】*vegetative endocarditis (続) 【続発性胆汁性肝硬変】*secondary biliary cirrhosis (略 PBC) (粟) 【粟粒結核】*miliary tuberculosis 【粟粒疹】*miliaria 【粟粒性無気肺】*miliary atelectasis [medo.jp]

• Hyperprolactinemia

  Laboratory tests showed hyperprolactinemia, normal electrolytes, and a normal lipid profile. [ncbi.nlm.nih.gov]

Treatment was started with 2-CdA for six 1-month 6 cycles (5 days of treatment in 1 week and repeated every month). [jamanetwork.com]

This chronic disease has no known established treatment. We report 8 cases of xanthoma disseminatum with treatment outcomes in long-term follow-up and provide a review of the medical literature. [mayoclinic.pure.elsevier.com]

We studied 15 articles on treatment of xanthoma disseminatum. Local treatment with cryotherapy, radiotherapy, surgery, and carbon dioxide lasers have been attempted with various results. [ncbi.nlm.nih.gov]

CNS involvement carries a poor prognosis in this otherwise benign condition. [ncbi.nlm.nih.gov]

Even with this escalation of treatment, progressive cases of XD typically have a poor prognosis. [dermatologyadvisor.com]

Prognosis often resistant to treatment Localization mucocutaneous ocular laryngeal pituitary central nervous system liver ( 16354260 ) See also systemic histiocytoses non-Langerhans cell histiocytoses dermal dendrocytes dendrocytic tumors (dendrocytic [humpath.com]

What is the Prognosis of Xanthoma Disseminatum? (Outcomes/Resolutions) The prognosis of Xanthoma Disseminatum (XD) depends on the type of condition and the symptoms that manifest. [dovemed.com]

Xanthoma disseminatum is a rare, benign, non-Langerhans' cell histiocytic disorder of unknown etiology. [ncbi.nlm.nih.gov]

Xanthoma Disseminatum: Case Report Abstract Xanthoma disseminatum is a rare, benign, non-Langerhans´ cell histiocytic disorder of unknown etiology. [adc.mef.hr]

Tumoral pathology > xanthoma disseminatum Xanthoma disseminatum is a rare, usually self- healing dermatologic disease of unknown etiology. Involvement of other organs and tissues including bone marrow, bone, and brain may be seen rarely in children. [humpath.com]

Sažetak Xanthoma disseminatum is a rare, benign, non-Langerhans´ cell histiocytic disorder of unknown etiology. [hrcak.srce.hr]

Definition / general Localized mass forming collection of lipid bearing histiocytes Terminology Also called xanthomatous polyp, xanthogranulomatous inflammation, xanthelasma Epidemiology Very rare in colon - stomach is most common gastrointestinal site [pathologyoutlines.com]

XD could be differentiated from BCH on the basis of epidemiological, clinical and histopathological findings. One hypothesis could link such circumscribed localization to some regional (dis-)immune factors (10). [medicaljournals.se]

Epidemiology Preferentially affects children, usually occurs by 10 years of age, with one-half of reported cases occurring in the first year of life. Twenty percent of the cases occur in adolescents and young adults. [atlasgeneticsoncology.org]

Etiology Pathophysiology The etiology and pathogenesis of XD are unknown. Some authors have speculated that the association with paraproteinemia suggests an immunologic basis for this disease. [dermatologyadvisor.com]

Department of Molecular Medicine, IRCCS San Matteo Foundation, University of Pavia, Pavia, 2 Unit of Dermatology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Via Pace 9, Milan, 3 Department of Oncology and Hematology, and 4 Department of Pathophysiology [medicaljournals.se]

Indeed, the different subtypes of NLH share largely common immune, histopathological and probably pathophysiological features, and their differential diagnosis is frequently based on some specific organ involvements. [karger.com]

Xanthomas associated with hyperlipidemia require treatment of the lipid disorder to reduce the xanthomas and prevent possible risks (such as atherosclerosis) (2). [empowher.com]

A thorough workup is essential to identify the underlying condition in order to initiate early treatment and to prevent later complications. [austinpublishinggroup.com]

Treatment of eruptive xanthoma involves dietary restriction, exercise, and drug therapy to control the hyperlipidemia and the diabetes. 2 Early recognition and proper control of hypertriglyceridemia can prevent sequelae such as acute pancreatitis. 3 [mdedge.com]

Lipoma disseminatum 1 Department of Medicine, Lady Hardinge Medical College and Smt.S.K.Hospital, New Delhi, India 2 Department of Medicine/Preventive Cardiology, Hamdard Institute of Medical Sciences and Research and HAH Centenary Hospital, Jamia Hamdard [jscisociety.com]