Presentation
Results presented to date of the large adjuvant and neoadjuvant trials incorporating capecitabine are encouraging and suggest that women with breast cancer might benefit from the activity of capecitabine early in the disease course. [ncbi.nlm.nih.gov]
Swiss pharmaceutical company Roche has presented data from a study which shows that its oral chemotherapy drug Xeloda (capecitabine) is as effective as the current standard treatment. [pmlive.com]
Gastrointestinal
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Diarrhea
The main nonhematologic toxicities were grade 2/3 nausea/vomiting (7 cycles; 5%), grade 2/3 neurotoxicity (10 cycles; 7%), grade 2/3 asthenia (8 cycles; 5.5%) and grade 2/3 diarrhea (6 cycles; 4%). There was no treatment-related death. [ncbi.nlm.nih.gov]
Interrupt, adjust dose, and/or treat symptoms if toxicity occurs (eg, hyperbilirubinemia, diarrhea, nausea, vomiting, hand-and-foot syndrome, stomatitis) (see full labeling); do not increase dose afterwards. [infectiousdiseaseadvisor.com]
Instruct patient to immediately report nausea, vomiting, diarrhea, mouth ulcers, swollen joints, temperature above 100.5 F (38 C), and other signs or symptoms of infection. • Tell patient to expect dosage adjustments during therapy. • Urge patient to [medical-dictionary.thefreedictionary.com]
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Intestinal Disease
disease, infection, coagulopathy • children younger than age 18. [medical-dictionary.thefreedictionary.com]
Diseases Rectal Diseases Bevacizumab Capecitabine Angiogenesis Inhibitors Angiogenesis Modulating Agents Growth Substances Physiological Effects of Drugs Growth Inhibitors Antineoplastic Agents Antimetabolites, Antineoplastic Antimetabolites Molecular [clinicaltrials.gov]
Diseases / Intestinal Neoplasms / Neoplasms, Colorectal / Rectal Carcinoma / Rectal Neoplasms 1 2RecruitingTreatment Colorectal Cancers 1 2RecruitingTreatment Colorectal Large Cell Neuroendocrine Carcinoma / Esophageal Large Cell Neuroendocrine Carcinoma [drugbank.ca]
Breast
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Nipple Discharge
It causes symptoms like a new breast lump or mass, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, scaliness, or thickening of the nipple or breast skin, and nipple discharge other than [breastcancer-news.com]
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Nipple Retraction
It causes symptoms like a new breast lump or mass, swelling of all or part of a breast, skin irritation or dimpling, breast or nipple pain, nipple retraction, redness, scaliness, or thickening of the nipple or breast skin, and nipple discharge other than [breastcancer-news.com]
Neurologic
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Meningism
[…] anti-ErbB1 and/or ErbB2 inhibitor therapy for breast cancer; neoadjuvant or adjuvant treatment with trastuzumab will be allowed provided the last dose was 6 months prior to enrollment in study Symptomatic or untreated brain metastases or carcinomatous meningitis [clinicaltrials.gov]
Urogenital
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Amenorrhea
In addition, between 1 and 10 percent of the patients experience constipation, headaches, and dizziness, eye problems, hair loss or hair thinning, abdominal pain, loss of appetite, high levels of bilirubin in the blood, amenorrhea, and loss of fertility [breastcancer-news.com]
Treatment
The activity of capecitabine in the first-line treatment of MBC is underpinned by its consistently high activity in MBC. [ncbi.nlm.nih.gov]
Prognosis
Featured 6,735 Community 48 Act Your Age When It Comes to Skin Care Act Your Age When It Comes to Skin Care Cancer Connect 12 hrs Cyramza Improves Survival in Poor-Prognosis Liver Cancer Cyramza Improves Survival in Poor-Prognosis Liver Cancer Cancer [news.cancerconnect.com]
Mucinous rectal cancer: effectiveness of preoperative chemoradiotherapy and prognosis. Ann Surg Oncol 2011; 18: 2232-2239. [pancreas.imedpub.com]
The relative 5-year survival for all cancer diagnoses today is 67%, and 36 % in the beginning of the 70s indicating that the prognosis for cancer patients has improved tremendously [ 4 ]. [link.springer.com]
Shin US, Yu CS, Kim JH, Kim TW, Lim SB, et al. (2011) Mucinous rectal cancer: effectiveness of preoperative chemoradiotherapy and prognosis. Ann Surg Oncol 18: 2232-2239. [acanceresearch.com]
Epidemiology
Tables at a glance Figures at a glance References Herszényi L, Tulassay Z (2010) Epidemiology of gastrointestinal and liver tumors. Eur Rev Med PharmacolSci 14: 249-258. [acanceresearch.com]
Prevention
Cancer Connect 3 days Overview of Melanoma Melanoma: Signs & Symptoms, Diagnosis, Screening, Prevention & Early Detection Cancer Connect 3 days Sunscreen May Reduce Risk of Melanoma Regular use of sunscreen may help prevent melanoma. [news.cancerconnect.com]
Capecitabine is designed to slow the growth of and kill colon cancer cells by preventing DNA synthesis inside cancer cells. [chemoexperts.com]
Researching Advancements in Cancer Vaccines Cancer vaccines can be used either in the prevention or the treatment of cancer. [news-medical.net]
Grade 3 is defined as ulceration (open sore or wound on the skin), moist desquamation (skin peeling), blistering, severe pain of the hands and feet, or severe discomfort that prevents the patient from completing daily activities. [rxight.com]