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Yersinia


Presentation

  • It is seen frequently in infants and young children who can present with severe, often life-threatening symptoms.[pediatrics.aappublications.org]
  • However, genomic sequencing has uncovered a host of other adhesins present in these organisms, the functions of which are only starting to be investigated.[ncbi.nlm.nih.gov]
  • We report the case of a man, who presented with mesenteric adenitis initially due to a Yersinia pseudotubercolosis infection, who was later diagnosed with Crohn's disease.[ncbi.nlm.nih.gov]
  • Some forms present with liver and spleen abscesses and have worse prognosis.[ncbi.nlm.nih.gov]
  • Here, we present an overview of how Yersinia and host factors are integrated in a regulatory network that orchestrates the subversion of host defense.[ncbi.nlm.nih.gov]
Plethora
  • A large repertoire of RNA-based regulatory mechanisms, including a plethora of cis- and trans-acting noncoding RNAs (ncRNAs), sensory RNA elements, regulatory RNA-binding proteins, and RNA-degrading enzymes have been uncovered lately as key players in[ncbi.nlm.nih.gov]
Vietnamese
  • A 49 years old Vietnamese male with a history of thalassemia, presented with gastrointestinal symptoms and signs of hemolysis. He was diagnosed with yersinia enterocolitis.[ncbi.nlm.nih.gov]
Streptococcal Infection
Right Lower Quadrant Tenderness
  • In older children, a pseudoappendicitis-like picture may be encountered with fever, abdominal pain, right lower quadrant tenderness, arthritis, and leukocytosis, similar to those in the present case. 7 10–15 Atypically, Y enterocolitica may cause a pharyngitis[pediatrics.aappublications.org]
Enthesopathy
  • Jacobs, HLA-B27-Associated Spondyloarthritis and Enthesopathy, Pediatric Rheumatology for the Practitioner, 10.1007/978-1-4757-6150-4_4, (360-408), (1993).[doi.org]
Oligoarthritis
  • Christel Gripenberg‐Lerche, Falk Hiepe, Rieke Alten, Wolfgang Keitel, Annemarie Groh, Jaakko Uksila, Ulrich Eggens, Kaisa Granfors and Jürgen Braun, No benefit of long‐term ciprofloxacin treatment in patients with reactive arthritis and undifferentiated oligoarthritis[doi.org]
Fear
  • How the plague bacillus and its transmission through fear were discovered: reminiscences from my year at the Pasteur Institute in Paris. Proc Natl Acad Sci USA 1995;92:7609-7611. Bibel DJ.[antimicrobe.org]
  • It has been present in the rodents of western North America ever since, as fear of the consequences of the outbreak on trade caused authorities to hide the dead of the Chinatown residents long enough for the disease to be passed to widespread species[en.wikipedia.org]
Excitement
  • Importantly, the analysis of Yersinia riboregulators has not only uncovered crucial elements and regulatory mechanisms governing host-pathogen interactions, it also revealed exciting new venues for the design of novel anti-infectives.[ncbi.nlm.nih.gov]

Workup

  • (See Pathophysiology, Etiology, Clinical Presentation, and Workup.) [7, 8] Classification Y enterocolitica is classified according to various distinct biochemical and serologic reactions.[emedicine.medscape.com]

Treatment

  • Carter, Reactive Arthritis: Defined Etiologies, Emerging Pathophysiology, and Unresolved Treatment, Infectious Disease Clinics of North America, 20, 4, (827), (2006).[doi.org]
  • Although the prognosis is not good in such cases, with high mortality rates, our patient recovered from the disease with appropriate treatment.[ncbi.nlm.nih.gov]
  • Faeces, biopsy specimens (by sigmoidoscopy), and serum were taken at the start, at regular intervals, and after treatment.[ard.bmj.com]
  • So far, surgical resection has been the only curative treatment, but new options became available with the application of imatinib (Glivec) as a specific molecular inhibitor.[ncbi.nlm.nih.gov]
  • Identifying Yersinia affects the role and choice of antibiotics in a child's treatment regimen.[ncbi.nlm.nih.gov]

Prognosis

  • Some forms present with liver and spleen abscesses and have worse prognosis.[ncbi.nlm.nih.gov]
  • Prognosis Yersiniosis is usually either self-limited or is responsive to therapy; however, reinfection is possible. Most patients with Y enterocolitica infection are symptomatic; however, asymptomatic carriage may occur.[emedicine.medscape.com]
  • Every year, thousands of cases of the plague are still reported to the World Health Organization, although with proper treatment, the prognosis for victims is now much better.[en.wikipedia.org]
  • Hellers G (1979) Crohn's disease in the Stockholm county 1955–74: a study of epidemiology, results of surgical treatment and long-term prognosis. Acta Chir Scand suppl 490: 1–84. View Article Google Scholar 14.[doi.org]

Etiology

  • Carter, Reactive Arthritis: Defined Etiologies, Emerging Pathophysiology, and Unresolved Treatment, Infectious Disease Clinics of North America, 20, 4, (827), (2006).[doi.org]
  • (See Pathophysiology, Etiology, Clinical Presentation, and Workup.) [7, 8] Classification Y enterocolitica is classified according to various distinct biochemical and serologic reactions.[emedicine.medscape.com]
  • The Gram stain and the etiology of lobar pneumonia, an historical note.[ncbi.nlm.nih.gov]
  • Rarely, it has been associated with sepsis. [1] [2] [3] Etiology United States No specific pattern of Yersinia pseudotuberculosis infection has been reported.[ncbi.nlm.nih.gov]
  • Yersinia pestis —etiologic agent of plague. Clin. Microbiol. Rev. 10 : 35 -66. Revazishvili, T., M. Kotetishvili, O. C. Stine, A. S. Kreger, J. G. Morris, Jr., and A. Sulakvelidze. 2004.[jcm.asm.org]

Epidemiology

  • Prevention and Control of Qinghai Province, Xining, China. 3 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China ruifuyang@gmail.com zmduams@163.com.[ncbi.nlm.nih.gov]
  • This article reports on Australia's first proven case of Yersinia enterocolitica intussusception, and reviews the clinical epidemiology of all known reported cases world-wide.[ncbi.nlm.nih.gov]
  • Epidemiology Pasteurella species are primarily pathogens of cattle, sheep, fowl, and rabbits. Humans become infected by handling infected animals.[ncbi.nlm.nih.gov]
  • Epidemiology of Yersinia Yersinia enterocolitica is transmitted via the fecal-oral route and is most often transmitted by eating or drinking food or water that has been contaminated by contact with infected animals or people.[ehagroup.com]
  • Epidemiology Occurrence in the United States Yersiniosis is rare in the absence of a breakdown in food-processing techniques.[emedicine.medscape.com]
Sex distribution
Age distribution

Pathophysiology

  • . – Pathophysiology of Yersinia infections; Host’s mechanisms of innate and adaptive immunity; Genetic bases of host susceptibility to plague; Resistance of pathogenic Yersinia to antibiotics; Evolution of pathogenic Yersinia.[research.pasteur.fr]
  • Pathophysiology As with other members of the genus Yersinia, Y enterocolitica is an invasive organism that appears to cause disease by tissue destruction.[emedicine.medscape.com]
  • Carter, Reactive Arthritis: Defined Etiologies, Emerging Pathophysiology, and Unresolved Treatment, Infectious Disease Clinics of North America, 20, 4, (827), (2006).[doi.org]
  • Pathophysiology One usually acquires Yersinia pseudotuberculosis from the gastrointestinal (GI) tract after consumption of contaminated food. A large inoculum is usually required to produce disease.[ncbi.nlm.nih.gov]

Prevention

  • YopK has been shown to control Yop translocation and prevent inflammasome recognition of the T3SS by the innate immune system.[ncbi.nlm.nih.gov]
  • As with all cases of diarrhea, fluids are given to prevent or treat dehydration.[healthychildren.org]
  • Prevent cross-contamination in the kitchen by: using separate cutting boards for meat and other foods carefully cleaning all cutting boards, counter-tops and utensils with soap and hot water after preparing raw meat.[health.govt.nz]
  • Prevent cross-contamination in the kitchen: Use separate cutting boards for meat and other foods. Carefully clean all cutting boards, counter-tops, and utensils with soap and hot water after preparing raw meat.[medicinenet.com]
  • Encourage public awareness of outbreaks, modes of transmission, and ways to prevent transmission.[emedicine.medscape.com]

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