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Yersinia Pseudotuberculosis


Presentation

  • Patients normally present with symptoms similar to those of appendicitis, due to mesenteric adenitis.[ncbi.nlm.nih.gov]
  • The girl presented with remittent fever, vomiting and non-oliguric acute renal failure with sterile pyuria and tubular reabsorptive dysfunction.[ncbi.nlm.nih.gov]
  • Abstract We report an adult case of Yersinia pseudotuberculosis colitis who presented with severe gastrointestinal bleeding. A 25-year-old male had admitted with fever, vomiting, body aches, and massive lower gastrointestinal bleeding.[ncbi.nlm.nih.gov]
  • Iron overload, which plays an important role in the pathogenesis of haemophilic arthropathy, may have increased the virulence of Y. pseudotuberculosis in the present case.[ncbi.nlm.nih.gov]
  • Abstract The successful isolation of Yersinia pseudotuberculosis from the stool of an asymptomatic family member of a patient with yersinia septicemia is presented. Cold enrichment permitted the isolation after 4 weeks of refrigerator incubatio,.[ncbi.nlm.nih.gov]
Fever of Unknown Origin
  • The patient had no history of immunosuppression and presented with a repeat case of haemarthrosis with a fever of unknown origin. Furthermore, he suffered from acute-on-chronic renal failure and non-ST segment elevation myocardial infarction.[ncbi.nlm.nih.gov]
Increased Susceptibility to Infections
  • We propose that, because of defects in mucosal barrier function and immunological function, patients with Crohn's may have increased susceptibility to infection by Yersinia sp.[ncbi.nlm.nih.gov]
Goiter
  • Extracts containing hTSHR were isolated from surgical thyroid tissue of patients with clinical and diagnostic signs of diffuse toxic goiter.[ncbi.nlm.nih.gov]
Polydipsia
  • Abstract A case concerning a young man presenting with polyuria and polydipsia which were preceded 1 month earlier by a febrile enteritis is reported.[ncbi.nlm.nih.gov]
Recurrent Vomiting
  • He had fever for 5 days after recurrent vomiting and diarrhea. Computed tomography scan was normal, but electroencephalogram (EEG) analyses showed generalized slow wave patterns.[ncbi.nlm.nih.gov]
Aphthous Ulceration
  • Colonoscopic examination revealed aphthous ulcers in the right colon, and mucosal biopsy culture grew Yersinia pseudotuberculosis. This case documents right colonic ulcers and bloody diarrhea with Yersinia pseudotuberculosis.[ncbi.nlm.nih.gov]
Low Back Pain
  • A 65-year-old man presented with low back pain and fever. He had a history of psoriasis vulgaris treated with adalimumab. The patient reported drinking adequate amounts of well water daily.[ncbi.nlm.nih.gov]
Polyuria
  • Abstract A case concerning a young man presenting with polyuria and polydipsia which were preceded 1 month earlier by a febrile enteritis is reported.[ncbi.nlm.nih.gov]
Uremia
  • Abstract Yersinia pseudotuberculosis septicemia and postdiarrheal hemolytic-uremia syndrome (HUS) developed in a 15-month-old boy after he ingested unpasteurized goat's milk.[ncbi.nlm.nih.gov]
Encephalopathy
  • We report the case of a 28-month-old boy with encephalopathy and acute tubulointerstitial nephritis possibly associated with Yersinia pseudotuberculosis (Yp) infection.[ncbi.nlm.nih.gov]

Workup

Pyuria
  • The girl presented with remittent fever, vomiting and non-oliguric acute renal failure with sterile pyuria and tubular reabsorptive dysfunction.[ncbi.nlm.nih.gov]
Abnormal Renal Function
  • Ultrasound examination revealed that the kidneys were markedly enlarged with diffuse hyperechogenicity in the cortex when the abnormal renal function was present and were restored in size and echogenicity when the renal function normalised.[ncbi.nlm.nih.gov]
Colonic Ulcer
  • This case documents right colonic ulcers and bloody diarrhea with Yersinia pseudotuberculosis.[ncbi.nlm.nih.gov]
Colitis
  • Abstract We report an adult case of Yersinia pseudotuberculosis colitis who presented with severe gastrointestinal bleeding. A 25-year-old male had admitted with fever, vomiting, body aches, and massive lower gastrointestinal bleeding.[ncbi.nlm.nih.gov]

Treatment

  • All intussusceptions were localized at the ileocolic region, and all patients completely recovered with Gastrografin enema and supportive treatment without complication and operation.[ncbi.nlm.nih.gov]
  • The Y. pseudotuberculosis septicaemia responded well to treatment with doxycycline orally, but the patient died 2 weeks later because of excessive bleeding from varicose veins of the oesophagus.[ncbi.nlm.nih.gov]
  • Treatment with troleandomycin was successful.[ncbi.nlm.nih.gov]
  • The patient was discharged with cure 12 days after the operation following gentamicin treatment. To our knowledge, there are only two reports about massive lower gastrointestinal bleeding due to Y. pseudotuberculosis.[ncbi.nlm.nih.gov]
  • Infection usually becomes apparent 5–10 days after exposure and typically lasts 1–3 weeks without treatment.[wikidoc.org]

Prognosis

  • Prognosis Most pseudotuberculosis cases are either minimally symptomatic or self-limited.[emedicine.com]

Etiology

  • Abstract Enteropathogenic Yersinia enterocolitica and Yersinia pseudotuberculosis are both etiological agents for intestinal infection known as yersiniosis, but their epidemiology and ecology bear many differences.[ncbi.nlm.nih.gov]
  • BACKGROUND: The etiology of Kawasaki disease (KD) is unknown. Reportedly, there is an association between KD and Yersinia pseudotuberculosis (YPT).[ncbi.nlm.nih.gov]
  • Y. pestis is the etiologic agent of plague; whereas Y. pseudotuberculosis causes a gastrointestinal infection primarily after the consumption of contaminated food.[ncbi.nlm.nih.gov]
  • Y pseudotuberculosis has also been implicated in the etiology of some cases of Kawasaki disease. [6] Because of its 97% DNA homology with the agent that causes plague, Yersinia pestis, Y pseudotuberculosis is believed to have been the progenitor of the[emedicine.com]
  • Rarely, it has been associated with sepsis. [1] [2] [3] Etiology United States No specific pattern of Yersinia pseudotuberculosis infection has been reported.[statpearls.com]

Epidemiology

  • The development of a fast and inexpensive typing system is necessary to facilitate epidemiological studies of Y. pseudotuberculosis infections.[ncbi.nlm.nih.gov]
  • Epidemiological studies on the outbreaks have been limited by the lack of accurate typing methods.[ncbi.nlm.nih.gov]
  • The epidemiology of this organism and the disease states caused by it are discussed with the suggestion that an association between it and some cases of the HUS might be found if sought.[ncbi.nlm.nih.gov]
  • Bacterial isolates were genetically indistinguishable, but no epidemiologic link between the 2 patients was established. HIV-related immunosuppression should be regarded as a risk factor for Y. pseudotuberculosis septicemia.[ncbi.nlm.nih.gov]
  • Evolutionary analysis suggests that epidemiologic advantages could cause this genotype's dominance.[ncbi.nlm.nih.gov]
Sex distribution
Age distribution

Pathophysiology

  • […] progenitor of the plague bacillus and is considered a model of bacterial evolution. [7] More optimistically, a specific strain of Y pseudotuberculosis, IP32953, has been modified into a potentially promising vaccine against bubonic and pneumonic plague. [8] Pathophysiology[emedicine.com]
  • Pathophysiology One usually acquires Yersinia pseudotuberculosis from the gastrointestinal (GI) tract after consumption of contaminated food. A large inoculum is usually required to produce disease.[statpearls.com]
  • The clinical pathophysiology of Y. pseudotuberculosis has many similarities to that of infections caused by Staphylococcus aureus and Streptococcus pyogenes, which are each known to produce a superantigen ( 38 ).[doi.org]
  • Francis, Environmental Regulation of Yersinia Pathophysiology, Frontiers in Cellular and Infection Microbiology, 10.3389/fcimb.2016.00025, 6, (2016).[doi.org]

Prevention

  • Author information 1 National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis[ncbi.nlm.nih.gov]
  • We found that virulent Y. pseudotuberculosis was able to prevent secondary granule release. The blocking effect was general, as the release of primary and tertiary granules was also reduced.[ncbi.nlm.nih.gov]
  • Targeting of LcrF offers a novel, antivirulence strategy for preventing Yersinia infection. A small molecule library was screened for inhibition of LcrF-DNA binding in an in vitro assay.[ncbi.nlm.nih.gov]
  • We suggest a mechanism whereby YopK functions to prevent unintended Yop delivery and thereby PMN disruption, resulting in necrosis-like cell death, which would enhance the inflammatory response favoring the host.[ncbi.nlm.nih.gov]
  • As with all cases of diarrhea, fluids are given to prevent or treat dehydration.[healthychildren.org]

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