After six months of follow-up, ZDV associated anemia was present among 32.7% (51/156) of the participants, and 43.1% of them were severe while about 45.2% were macrocytic type. [ncbi.nlm.nih.gov]

Marketed presentations: Pack containing 60 film-coated tablets. Medicinal speciality authorised by the Ministry of Health. Certificate Nº 49157 Laboratorio DOSA S.A. Girardot 1369 (C1427AKC) Buenos Aires, Argentine. Pharmaceutical Director: María C. [laboratoriodosa.com]

• Fatigue

  RESULTS: The most frequent clinical side effect was fatigue (in 23 cases, 88.5%), and gastroenterological symptoms were the second most common side effects in HCP with PEP. [ncbi.nlm.nih.gov]

  Notify your doctor immediately if you have: dark urine, yellowing of the skin or eyes, abdominal or stomach pain, unusual fatigue, muscle aches, rapid breathing, drowsiness, symptoms of infection such as persistent fever or sore throat. [web.archive.org]

  Adverse side effects may include anemia, leukopenia, muscle fatigue, muscle wasting, nausea and headaches. 6, record 1, English, - zidovudine Record 1, French Record 1, Domaine(s) Record 1, Synonyms, French zidovudine 3, record 1, French, zidovudine correct [btb.termiumplus.gc.ca]

  Some zidovudine-treated patients with normal muscle strength experience excessive fatigue, myalgia, or transient mild CK elevations that improve when zidovudine is stopped. [link.springer.com]

  Side effects: nausea, vomiting, fatigue, anaemia (low red blood cells), fat loss, muscle pain and weakness. Darkening of skin and nails in people of African origin. Other notes: do not use with d4T. Methadone may increase AZT levels. [i-base.info]

• Falling

  Of the 60 children analysed, 45 (75%) showed a significant fall in Hb (>1 g/dl). A majority developed grade 1 anaemia (14 [31%]) while only three (6%) developed grade 4 anaemia. [ncbi.nlm.nih.gov]

  The emergence of drug-resistant strains coincides with a fall in the effectiveness of the drug. If zidovudine is taken as a single drug treatment, resistance emerges within a few months. [aidsmap.com]

  The Vernal (Spring) Equinox in the Northern Hemisphere is the Autumnal (Fall) Equinox in the Southern Hemisphere. more Try the Night Sky Map! Find and track planets in the sky with our new Interactive Night Sky Map. [timeanddate.com]

  There are informal water caches that are reliably stocked during the spring and fall for trail travelers, easing the burden. [bikepacking.com]

• Asymptomatic

  Abstract An asymptomatic HIV-positive patient with Philadelphia chromosome positive chronic myelogenous leukemia (CML) was treated by interferon-a (IFN-a) for four years. [ncbi.nlm.nih.gov]

  Patients who are HIV positive and have a CD4 count 500/mm 3, asymptomatic HIV infection, early and late symptomatic HIV disease, prevention of perinatal transfer of HIV during pregnancy. Pediatric patients, postexposure chemoprophylaxis. [robholland.com]

  An estimated 30 percent to 40 percent infected pregnant women risk transmission of HIV-1 to their infants, whether they be symptomatic or asymptomatic. [clinicaltrials.gov]

  The largest single study of zidovudine monotherapy in asymptomatic HIV infection, known as Concorde, suggested that there was no advantage in starting zidovudine before symptoms develop in the longer term. [aidsmap.com]

• Nausea

  Medicines to control nausea and headache can be prescribed before starting zidovudine. Nausea and vomiting may also be reduced by making the following adjustments to diet: Taking zidovudine before meals. [aidsmap.com]

  The commonest side-effects of AZT are nausea, vomiting, headache, dizziness, fatigue, weakness and muscle pain. These often occur in the early weeks of treatment. Medicines to control nausea and headache can be prescribed before starting AZT. [web.archive.org]

  Lamivudine and zidovudine can cause side effects ranging from fever and chills to nausea and vomiting. [sharecare.com]

  GI: Nausea, diarrhea, vomiting, anorexia, GI pain. Hematologic: Bone marrow depression, granulocytopenia, anemia. Respiratory: Cough, wheezing. Skin: Rash, itching, diaphoresis. [robholland.com]

  Treatment-emergent adverse events reported in more than 2% of patients included nausea (5%), diarrhea (5%), headache (3%) and insomnia (3%). [thebodypro.com]

• Abdominal Pain

  The patient had been receiving standard doses of zidovudine for 5 months when she was hospitalized because of the rapid onset of abdominal pain, nausea, and vomiting. The most significant findings at autopsy were massive hepatomegaly and steatosis. [ncbi.nlm.nih.gov]

  pain) symptoms of lactic acidosis (e.g., weight loss, fatigue, generally feeling ill, abdominal pain, shortness of breath) along with an enlarged liver and symptoms of liver problems (e.g., nausea, vomiting, abdominal pain, weakness, diarrhea) symptoms [medbroadcast.com]

  If you develop signs of pancreatitis (e.g., upper left abdominal pain, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen), contact your doctor. [uniprix.com]

• Severe Abdominal Pain

  Patients taking zidovudine should inform their doctor if they experience severe abdominal pain, shortness of breath, unusual tiredness or weakness, unusual bleeding or bruising, sore throat, fever or an injury that does not heal. [aidsmap.com]

  Patients taking AZT should inform their doctor if they experience severe abdominal pain, shortness of breath, unusual tiredness or weakness, unusual bleeding or bruising, sore throat, fever or an injury that does not heal. [web.archive.org]

• Persistent Vomiting

  If you experience symptoms of liver problems (e.g., abdominal pain, persistent vomiting, feeling unwell, fever, itching, yellowing of the skin and eyes, dark urine), contact your doctor immediately. [uniprix.com]

• Muscle Weakness

  If you experience muscle pain or muscle weakness, call your doctor immediately. [medlineplus.gov]

  This medication may also cause muscle problems (myopathy). Seek immediate medical attention if you develop symptoms of myopathy (such as wasting or decrease in muscle size, muscle weakness/pain/tenderness, weight loss). [webmd.com]

  These include hypersensitivity reaction or rash, a buildup of lactic acid in the blood ( lactic acidosis ), liver problems, muscle weakness ( myopathy ), and blood disorders such as extremely reduced numbers of red blood cells (severe anemia ) or reduced [aidsinfo.nih.gov]

  This medication may also cause muscle problems (myopathy). Seek immediate medical attention if you develop symptoms of myopathy (such as wasting or decrease in muscle size, muscle weakness/ pain /tenderness, weight loss ). [medicinenet.com]

  Regular Paper 70 Downloads 41 Citations Abstract Zidovudine-induced myopathy is characterized by reversible muscle weakness, wasting, myalgia, fatigue, and elevated creatine kinase (CK). [link.springer.com]

• Pruritic Rash

  The exposed worker stopped ddI after 8 days because of symptoms but continued to take d4T and NVP, stopping at day 24 because of a generalized macular pruritic rash and mild thrombocytopenia. Seroconversion was documented at 3 months. [web.archive.org]

• Suggestibility

  Findings in this case suggest that qualities of an inoculum and/or the route of transmission are important determinants in the subsequent clinical course of HIV disease. [ncbi.nlm.nih.gov]

• Headache

  It must also be used cautiously in patients with preexisting bone marrow suppression. adverse effects Headache, GI disturbances, insomnia, flulike symptoms, rash, fatigue, myalgia, and central nervous system symptoms may occur during the first weeks of [medical-dictionary.thefreedictionary.com]

  Some of the less serious side effects caused by one or all three drugs, which may dissipate as you adjust to the medication include: diarrhea, headaches, nausea, stomach pain and tiredness. [sharecare.com]

  Monitor for common adverse effects, especially severe headache, nausea, insomnia, and myalgia. Patient & Family Education Contact physician promptly if health status worsens or any unusual symptoms develop. [robholland.com]

  Side effects include headaches, nausea, and discoloration of fingernails and toenails. More severe side effects include anemia and bone marrow suppression. [en.wikibooks.org]

  The commonest side-effects of zidovudine are nausea, vomiting, headache, dizziness, fatigue, weakness and muscle pain. These often occur in the early weeks of treatment. [aidsmap.com]

• Tremor

  Frequency not reported : Decreased reflexes, hyperalgesia, numbness, status epilepticus, Wernicke's syndrome Postmarketing reports : Seizures, dizziness, paresthesia, somnolence, vertigo, hearing loss, loss of mental acuity, syncope, taste perversion, tremor [drugs.com]

  These included: loss of mental acuity, muscle spasms, rectal bleeding, and tremors. Anemia, one of AZT’s common side effects, is the depletion of red blood cells, and, according to Duesberg, “Red blood cells are the one thing you cannot do without. [spin.com]

  Delayed / 15.0-15.0 rash / Early / 12.0-12.0 asthenia / Delayed / 9.0-9.0 diarrhea / Early / 8.0-8.0 rhinorrhea / Early / 8.0-8.0 nasal congestion / Early / 8.0-8.0 otalgia / Early / 7.0-7.0 irritability / Delayed / 0-6.0 weight loss / Delayed / 0-6.0 tremor [m.pdr.net]

The patient underwent a workup to rule out possible causes for this prolonged bleeding time; all studies were negative. A review of his history identified that he was self-medicating with ibuprofen while taking zidovudine. [ncbi.nlm.nih.gov]

• Neutropenia

  Other significant effects may include neutropenia and hepatic dysfunction. A 4-day-old male infant who received two inadvertent 10-fold overdoses of AZT while being treated for HIV postnatal prophylaxis. [ncbi.nlm.nih.gov]

  Warnings/Precautions: Risk of hematologic toxicity/bone marrow suppression; monitor CBCs esp. in advanced HIV-1 disease; interrupt dose if anemia or neutropenia occurs. Myopathy with prolonged use. [empr.com]

  See Table 2. 2.4 Patients with Severe Anemia and/or Neutropenia Significant anemia (hemoglobin less than 7.5 g per dL or reduction greater than 25% of baseline) and/or significant neutropenia (granulocyte count less than 750 cells per mm3 or reduction [globalrph.com]

• Glucose Increased

  […] of fatty substances called triglycerides increased levels of LDL-cholesterol (low-density lipoprotein) or "bad" cholesterol increased levels of sugar (glucose) increased levels of the hormone insulin decreased sensitivity to insulin (insulin resistance [catie.ca]

• Neutrophil Count Decreased

  The mean leucocyte ( Figure 2 B) and neutrophil ( Figure 2 C) counts decreased slightly until 35 wk and then increased sharply until delivery, with a more rapid decrease and subsequent increase in women randomized to the long regimen. [web.archive.org]

CD4 cell counts, viral RNA loads, and treatment changes were analyzed in a cohort of treatment success and failures. [ncbi.nlm.nih.gov]

Treatment HHV-8 / KSHV / KSHV Inflammatory Cytokine Syndrome (KICS) 1 2 Recruiting Treatment Human Immunodeficiency Virus (HIV) Infections 1 2 Recruiting Treatment Metastatic Colorectal Cancers 1 2 Suspended Treatment Human Immunodeficiency Virus (HIV [drugbank.ca]

Abstract Adult T-cell leukemia-lymphoma (ATLL) is an aggressive malignancy with poor prognosis that is incurable by conventional drugs. [bloodjournal.org]

INTRODUCTION Section: Adult T-cell leukemia-lymphoma (ATL) is an aggressive malignancy of activated T cells associated with the human T-cell lymphotropic virus type-I (HTLV-I). 1 Diversity in clinical features and prognosis of patients with ATL have led [jco.ascopubs.org]

Anemia at the beginning of ART is an important parameter for the short and long term prognosis [ 4 ]. ART generally improves HIV-associated anemia [ 3, 4 ], but some ARVs may cause anemia. [omicsonline.org]

HIV-1 RNA results from the assay can be used to assess prognosis of disease progression and to monitor the effects of antiretroviral therapy by measuring changes in HIV-1 RNA levels during the course of therapy. [fda.gov]

THE development of a rational therapy against the etiologic agent of the acquired immunodeficiency syndrome (AIDS) 1 2 3 was made possible by the discovery that a cytopathic retrovirus, now called the human immunodeficiency virus (HIV), caused the disorder [doi.org]

* Heart Septal Defects, Ventricular/diagnosis Heart Septal Defects, Ventricular/epidemiology Heart Septal Defects, Ventricular/etiology Humans Infant Infectious Disease Transmission, Vertical/prevention & control* Lamivudine/administration & dosage Lamivudine [ncbi.nlm.nih.gov]

Introduction The rapid worldwide spread of acquired immuno-deficiency syndrome (AIDS) has prompted an intense research effort to try to discover compounds that can effectively inhibit the human immunodeficiency virus (HIV), 1 the etiological agent of [scielo.br]

MeSH terms Adult Africa South of the Sahara/epidemiology Anemia/epidemiology* Anti-HIV Agents/therapeutic use* Female HIV Infections/blood HIV Infections/drug therapy* HIV Infections/epidemiology HIV Infections/prevention & control HIV-1/isolation & purification [ncbi.nlm.nih.gov]

Despite extensive epidemiologic and phylogenetic evidence, however, CBWT of HIV continues to be overlooked. [aidsperspective.net]

[Article] VanWert AL, Gionfriddo MR, Sweet DH: Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. Biopharm Drug Dispos. 2010 Jan;31(1):1-71. doi: 10.1002/bdd.693. [go.drugbank.com]

J Pharmacol Exp Ther. 2002 Mar;300(3):918-24. [ PubMed:11861798 ] VanWert AL, Gionfriddo MR, Sweet DH: Organic anion transporters: discovery, pharmacology, regulation and roles in pathophysiology. [drugbank.ca]

In Pharmacotherapy: A Pathophysiologic Approach ; DiPiro, J. T.; Talbert, R. L.; Yee, G. C.; Matzke, G. R.; Wells, B. G.; Posey, L. M. eds.; McGraw Hills Publishers: Australia, 7 th ed, 2008, ch 129. [ Links ] 9. Pan-Zhou, X. [scielo.br]

It is not a cure for HIV and does not prevent the passing of HIV to others. This medication is also used in pregnant women to prevent spreading the virus to the fetus. [web.archive.org]

Abstract To prevent mother-to-child-transmission of HIV-1, the 2010 WHO guidelines recommended prenatal zidovudine (ZDV) monotherapy (option A). [ncbi.nlm.nih.gov]