The purpose of the present paper was to remind physicians that hypothermia is a possible side-effect of combining zotepine, valproate,and benzodiazepine. [ncbi.nlm.nih.gov]

The formulations of the present invention are suitable for use as drops. Therefore a further aspect of the present invention provides the formulations described herein in conjunction with a means for delivering drops. [google.ch]

• Orthostatic Hypotension

  Side Effects of Zotepine 25mg: Common side effects of Zotepine include Tachycardia, Hypotension, Orthostatic hypotension Palpitations, Hyperprolactinaemia, Weight gain. [sastimedicine.com]

  Orthostatic hypotension Palpitations Hyperprolactinaemia Weight gain (produces a similar degree of weight gain to that seen with clozapine and olanzapine treatment)[8] Somnolence (2nd highest effect size for causing sedation out of fifteen antipsychotics [en.wikipedia.org]

• Motor Restlessness

  These include dyskinesias such as repetitive, involuntary, and purposeless body or facial movements, Parkinsonism (cogwheel muscle rigidity, pill-rolling tremor and reduced or slowed movements), akathisia (motor restlessness, especially in the legs, and [library.neura.edu.au]

• Suggestibility

  High quality evidence suggests zotepine results in greater study retention than placebo. Moderate to low quality evidence suggests a greater clinical response with zotepine than placebo, although zotepine may result in more sleep problems. [library.neura.edu.au]

  These three cases of alopecia areata suggest that the antipsychotic drugs may induce autoimmune disease through their neuropsychological effect. [ncbi.nlm.nih.gov]

• Agitation

  Acutely ill, schizophrenic patients frequently require management of agitation. [ncbi.nlm.nih.gov]

  No concomitant psychotropic medications will be used during the study except for lorazepam, which are given for severe agitation or insomnia. [clinicaltrials.gov]

  Common side effects of Zotepine Headache, Dryness in mouth, Sleepiness, Anxiety, Weight gain, Insomnia (difficulty in sleeping), Agitation, Sweating, Blurred vision, Depression, Constipation, Increased heart rate Expert advice for Zotepine Take it at [1mg.com]

• Seizure

  Seizures are one of these adverse effects. Almost all first and second generation antipsychotics elicit dose-dependent lowering of seizure threshold, indicating increased seizure risk at higher drug dosages. [ncbi.nlm.nih.gov]

  Twenty-two patients had grand mal seizures during the administration periods. The incidence of the seizure was 17.1% and was higher than that in previous reports. The average duration of zotepine administration before the seizure was 48.3 days. [unboundmedicine.com]

• Akathisia

  […] may also cause less akathisia and dystonia. [library.neura.edu.au]

  The haloperidol group reported a higher incidence of treatment-related adverse events, especially parkinsonism and akathisia, compared to the zotepine group. Serum uric acid decreased more in the zotepine group than in the haloperidol group. [ncbi.nlm.nih.gov]

• Myoclonus

  […] prolongation Hyperthermia Hypothermia Increased serum creatinine Hyperglycaemia Hypoglycaemia Hyperlipidaemia Thirst Urinary incontinence Rare[1][3] Angle-closure glaucoma Agranulocytosis Neutropaenia Eosinophilia Leukocytopenia Hypoesthesia Anaemia Myoclonus [en.wikipedia.org]

• Generalized Tonic-Clonic Seizure

  We report the occurrence of myoclonic seizure progressing to generalized tonic-clonic seizures with zotepine along with clear temporal association of dose dependent modulation evident in this case. [ncbi.nlm.nih.gov]

• Hypouricemia

  […] dyskinesia Neuroleptic malignant syndrome Laryngeal edema Urinary retention Depression Ataxia Amnesia Seizure (dose-dependent risk)[2] Metabolic syndrome Diabetes mellitus type II Cholestasis Increased liver enzymes Photosensitivity Exanthema Pruritus Hypouricemia [en.wikipedia.org]

• Uric Acid Decreased

  Serum uric acid decreased more in the zotepine group than in the haloperidol group. [ncbi.nlm.nih.gov]

• Prolactin Decreased

  Serum uric acid and prolactin decreased more in the zotepine group than the risperidone group (P < 0.001 and P = 0.018, respectively).Zotepine seemed to be as effective as risperidone in treating hospitalized, acutely ill, schizophrenic patients with [ncbi.nlm.nih.gov]

• Prolonged QT Interval

  • Patients with prolonged QT interval, a type of ECG abnormality. • Patients who take sibutramine for treating obesity. [medindia.net]

  Increased risk of arrhythmias with drugs that prolong QT interval or cause hypokalaemia. Increased zotepine concentration with fluoxetine, diazepam. Increased CNS depresssion with alcohol, CNS depressants. [mims.com]

  People with a personal or family history of an abnormal heart rhythm seen on a heart monitoring trace or ECG as a 'prolonged QT interval'. [netdoctor.co.uk]

  QT interval. [6] Metabolic syndrome, most commonly related to long-term olanzapine and clozapine use, is associated with weight gain, diabetes, and cardiovascular disease. [emedicine.medscape.com]

Licht, Hans-Jürgen Möller, Siegfried Kasper and WFSBP Task Force on Treatment Guide, The World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Biological Treatment of Bipolar Disorders: Update 2009 on the Treatment of Acute [doi.org]

During further treatment the improvement remaind stable in the responder group, while 1 nonresponder improved after 3 weeks of treatment. [ncbi.nlm.nih.gov]

Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource. [books.google.es]

The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia 2004;45:1613-22. 2. Alldredge BK. Seizure risk associated with psychotropic drugs: clinical and pharmacokinetic considerations. Neurology 1999;53(Suppl 5):68-75. 3. [ijp-online.com]

Antipsychotic drugs also require to be effective in prevention of recurrence. [ncbi.nlm.nih.gov]

Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. [tabletwise.com]

EFFICACY Positive symptoms of schizophrenia Schizophrenia in acute exacerbation Negative symptoms of schizophrenia Refractory schizophrenia Efficacy against hostility Efficacy against cognitive symptoms Relapse prevention 21. [slideshare.net]

The anti-oxidant prevents the formation of Zotepine N-oxide. [google.ch]

This invention relates, more particularly, to use of zotepine or its pharmaceutically acceptable salt as a uric acid-lowering agent for prophylaxis and therapy to human being, to method for preventing or treating gout by administering zotepine or its [patents.google.com]