CD3+CD4-CD8+NK- large granular lymphocytosis with neutropenia and evidence for clonality and T-cell receptor gene rearrangement: two pediatric cases.

2002 Aug-Sep: ACant; PDarbyshire; AGennery; BGibson; SHarris; EHodges; MTKrishna; FLLavender; JLSmith; RWilkie;

J Pediatr Hematol Oncol.2002 Aug-Sep;24(6):495-8.

NLM PMID: 12218601

Article abstract

The authors describe two pediatric cases of large granular lymphocytosis presenting early in the second decade of life with neutropenia and sepsis. They are among the youngest described in the literature. This report focuses on the advantages of detailed immunophenotypic and molecular analysis and highlights some of the controversies and uncertainties in the management of these patients, particularly the choice of immunosuppressive therapy. Immunosuppressive therapy in the two children described in this report resulted in improvement of neutropenia and clinical status, but this was not accompanied by the disappearance of the clonal population.

Research Topics
• Diseases
   Lymphocytosis
   Neutropenia

Title and Abstract from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Data mined from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Last MEDLINE®/PubMed® update: 1st of December 2015