Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway.

2011: JChen; XKang; XLi; XLi; QLiang; XSun; LTao; XYe;

Brain Res.2011;1382:9-18.10.1016/j.brainres.2011.01.015.

NLM PMID: 21241673

Article abstract

Oxidative stress plays an important role in Parkinson's disease and other neurodegenerative disorders. Salidroside, a phenylpropanoid glycoside isolated from Rhodiola rosea L., has potent antioxidant properties. In the present study, we investigated the protective activity of salidroside against 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in PC12 cells. We found that incubation of PC12 cells with salidroside prior to MPP(+) exposure significantly reduced cell apoptosis and attenuated collapse of the mitochondrial membrane potential (MMP). Furthermore, salidroside inhibited the MPP(+)-induced nitric oxide (NO) increase and overexpression of nNOS and iNOS and suppressed accumulation of reactive oxygen species (ROS) and intracellular free Ca(2+). Our results show that the protective effects of salidroside on PC12 cells are mediated, at least in part, by inhibition of the NO pathway.

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Last MEDLINE®/PubMed® update: 1st of December 2015