The endogenous tripeptide Tyr-Gly-Gly as an extracellular metabolite of enkephalins in rat brain: origin and metabolism.

1986: BGiros; CGros; CLlorens-Cortes; JCSchwartz;

NIDA Res Monogr.1986;75:271-4.

NLM PMID: 3123944

Article abstract

The tripeptide Tyr-Gly-Gly (YGG) was established as an endogenous constituent in rat brain. Its origin from enkephalin neurons is suggested by its regional distribution paralleling that of (Met5)-enkephalin (YGGFM), its decrease following kainate-induced ablation of the striato-pallidal neurons and its enhanced formation following depolarization of pallidal slices. Enkephalinase (EC 3.4.24.11) is selectively responsible for endogenous YGG formation in vitro and in vivo.

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Last MEDLINE®/PubMed® update: 1st of December 2015