Top 20 of Cell Transformation, Viral

Article title # Publications/# Citations

SV40-transformed simian cells support the replication of early SV40 mutants.

1981: YGluzman;

869

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes.

1983 Aug 18-24: HLand; LFParada; RAWeinberg;

594

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.

1986: RAxel; PRClapham; AGDalgleish; PJMaddon; JSMcDougal; RAWeiss;

575

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine.

1980: THunter; BMSefton;

569

T antigen is bound to a host protein in SV40-transformed cells.

1979: LVCrawford; DPLane;

501

The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

1982: CMGorman; BHHoward; GTMerlino; IPastan; MCWillingham;

490

The p53 tumour suppressor gene.

1991: CAFinlay; AJLevine; JMomand;

465

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

1990: PMHowley; AJLevine; BAWerness;

451

Disruption of epithelial cell-matrix interactions induces apoptosis.

1994: HFrancis; SMFrisch;

434

Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton.

1988: KBurridge; KFath; TKelly; GNuckolls; CTurner;

411

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.

1981: SMAstrin; WSHayward; BGNeel;

404

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.

1982: YHinuma; IMiyoshi; MYoshida;

391

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.

1984 Feb 9-15: JDownward; EMayes; JSchlessinger; GScrace; PStockwell; NTotty; AUllrich; MDWaterfield; YYarden;

388

Stable replication of plasmids derived from Epstein-Barr virus in various mammalian cells.

1985 Feb 28-Mar 6: BSugden; NWarren; JLYates;

387

Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells.

1979: AJLevine; DILinzer;

372

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture.

1983 Aug 18-24: HERuley;

370

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

1992: JRNevins;

369

Binary Agrobacterium vectors for plant transformation.

1984: MBevan;

362

Identification of two distinct regulatory regions adjacent to the human beta-interferon gene.

1983: DDiMaio; TManiatis; KZinn;

343

Epstein-Barr virus: 40 years on.

2004: ABRickinson; LSYoung;

341