Top 20 of Genetic Predisposition to Disease

Article title # Publications/# Citations

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

2007: Wellcome Trust Case Control Consortium;

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Finding the missing heritability of complex diseases.

2009: MBoehnke; LRCardon; AChakravarti; JHCho; AGClark; FSCollins; NJCox; EEEichler; ... GGibson; DBGoldstein; AEGuttmacher; JLHaines; LAHindorff; DJHunter; AKong; LKruglyak; TFMackay; TAManolio; EMardis; SAMcCarroll; MIMcCarthy; EMRamos; CNRotimi; MSlatkin; DValle; PMVisscher; ASWhittemore;

1365

An integrated encyclopedia of DNA elements in the human genome.

2012: ENCODE Project Consortium;

1101

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

2009: FSCollins; LAHindorff; HAJunkins; TAManolio; JPMehta; EMRamos; PSethupathy;

1019

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

2003: ABraithwaite; ACaspi; IWCraig; HHarrington; JMartin; JMcClay; JMill; TEMoffitt; ... RPoulton; KSugden; ATaylor;

980

The future of genetic studies of complex human diseases.

1996: KMerikangas; NRisch;

841

Complement factor H polymorphism in age-related macular degeneration.

2005: CBarnstable; MBBracken; EYChew; FLFerris; CHaynes; AKHenning; JHoh; RJKlein; ... SMMane; STMayne; JOtt; RSSackler; JPSanGiovanni; JYTsai; CZeiss;

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Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.

2007: Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research; PAlmgren; DAltshuler; KArdlie; RBarry; KBengtsson Boström; ABerglund; BBlumenstiel; ... WBrodeur; NPBurtt; JCamarata; JCarlson; HChen; NChia; GWChirn; MJDaly; PIde Bakker; MDeFelice; MFava; JCFlorez; SBGabriel; DGage; CGates; LGianniny; JGibbons; LGroop; CGuiducci; RHackett; LHall; BHandsaker; CHealy; JNHirschhorn; JHolmkvist; TEHughes; BIsomaa; SKathiresan; ELaurila; GLettre; ULindblad; HNLyon; VLyssenko; QMa; OMelander; JMeyer; CNewton-Cheh; KNguyen; PNilsson; MNizzari; MOrho-Melander; HParikh; MParkin; SPurcell; LRåstam; DRichardson; DRicke; JJRoix; RSaxena; MSjögren; CSougnez; EKSpeliotes; MSterner; ASurti; MSvensson; MSvensson; MRTaskinen; RTewhey; TTuomi; BFVoight;

815

The endophenotype concept in psychiatry: etymology and strategic intentions.

2003: IIGottesman; TDGould;

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.

2001: SAlmer; JBelaiche; VBinder; JPCézard; MChamaillard; JFColombel; ACortot; YFinkel; ... MGassull; CGower-Rousseau; JPHugot; PLaurent-Puig; SLesage; JMacry; RModigliani; CAO'Morain; MSahbatou; GThomas; CTysk; HZouali;

782

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.

2007: GRAbecasis; CWBark; MWBarnhart; RNBergman; MBoehnke; LLBonnycastle; TABuchanan; PSChines; ... FSCollins; KNConneely; CJDing; KFDoheny; WLDuren; MRErdos; JLGoldstein; KNHetrick; THu; AUJackson; LKinnunen; XYLi; YLi; KLMohlke; NNarisu; LProkunina-Olsson; RPruim; EWPugh; NLRiebow; JSaramies; LJScott; AGSprau; HMStringham; AJSwift; MTong; JTuomilehto; TTValle; RMWatanabe; LWatkins; PPWhite; CJWiller; FXiang; RXiao;

772

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.

2007: JCBarrett; IBarroso; YBen-Shlomo; AJBennett; LRCardon; ASDoney; SEbrahim; SEllard; ... KSElliott; LFerrucci; TMFrayling; RMFreathy; CJGroves; LWHarries; ATHattersley; GAHitman; MRJarvelin; FKarpe; BKnight; HLango; DALawlor; CMLindgren; RJLoos; MIMcCarthy; DMelzer; ADMorris; ARNess; KROwen; CNPalmer; AMPatch; JRPerry; NWRayner; SMRing; BShields; GDSmith; USovio; NJTimpson; MWalker; NJWareham; MNWeedon; EZeggini;

751

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease.

2001: JPAchkar; TMBayless; DKBonen; SRBrant; HBritton; FFChen; JHCho; RHDuerr; ... SBHanauer; NInohara; RKaraliuskas; BSKirschner; TMoran; DLNicolae; GNuñez; YOgura; RRamos;

716

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

2009: International Schizophrenia Consortium; MCO'Donovan; SMPurcell; PSklar; JLStone; PFSullivan; PMVisscher; NRWray;

656

A genome-wide association study identifies novel risk loci for type 2 diabetes.

2007: DJBalding; BBalkau; ABélisle; PBoutin; GCharpentier; CDina; PFroguel; SHadjadj; ... BHeude; TJHudson; DMeyre; AMontpetit; CPolychronakos; BIPosner; MPrentki; AVPshezhetsky; GRocheleau; JRung; DSerre; LShen; RSladek; DVincent;

655

Genome-wide association studies for complex traits: consensus, uncertainty and challenges.

2008: GRAbecasis; LRCardon; DBGoldstein; JNHirschhorn; JPIoannidis; JLittle; MIMcCarthy;

634

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.

2007: Wellcome Trust Case Control Consortium (WTCCC); JCBarrett; LRCardon; ASDoney; SEllard; KSElliott; TMFrayling; RMFreathy; ... CJGroves; LWHarries; ATHattersley; GAHitman; BKnight; HLango; CMLindgren; JLMarchini; MIMcCarthy; ADMorris; APMorris; KROwen; JRPerry; NWRayner; BShields; NJTimpson; MWalker; MNWeedon; EZeggini;

630

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

1994: LMBennett; CCochran; WDing; PAFutreal; KHarshman; QLiu; YMiki; DShattuck-Eidens; JSwensen; STavtigian;

608

Strong association of de novo copy number mutations with autism.

2007: JBregman; WChung; DHGeschwind; TCGilliam; PKGregersen; JHicks; VJobanputra; JKendall; ... MCKing; AKrasnitz; BLakshmi; DLedbetter; ATLee; YHLee; TLehtimäki; ALeotta; CLese-Martin; DMalhotra; DPai; KPuura; JSebat; DSkuse; SJSpence; JSSutcliffe; JTroge; TWalsh; DWarburton; MWigler; BYamrom; KYe; SYoon; RZhang;

601

Genome-wide association study identifies novel breast cancer susceptibility loci.

2007: AOCS Management Group; kConFab; SEARCH Collaborators; SAhmed; SHAhn; BHAlexander; CKAxelsson; DGBallinger; ... JBeesley; JBenítez; NBogdanova; SEBojesen; RBowman; HBrauch; PBrennan; LBrinton; IWBrock; SChanock; XChen; GChenevix-Trench; FJCouch; ACox; DGCox; DRCox; NEDay; PDevilee; MMDoody; TDörk; AMDunning; DFEaston; DEccles; HEerola; DGEvans; RFagerholm; HField; OFletcher; VGaborieau; MGarcia-Closas; GGGiles; AGonzález-Neira; ELGoode; CAHaiman; PHall; UHamann; SEHankinson; JHartikainen; CSHealey; BEHenderson; JLHopper; DJHunter; CEJacobi; NJohnson; CJustenhoven; DKang; VKataja; JGKlijn; YDKo; LKKolonel; VMKosma; LLe Marchand; JLissowska; JLiu; YLLow; RLuben; GMacpherson; AMannermaa; MMcCredie; HMeijers-Heijboer; KBMeyer; RLMilne; JMorrison; HNevanlinna; DYNoh; BGNordestgaard; FOdefrey; JEOlson; BPeplonska; JPeto; PDPharoah; BAPonder; KAPooley; NRahman; MWReed; GRibas; FRivadeneira; SSangrajrang; CSchroen; PSchürmann; SSeal; CYShen; AJSigurdson; MSouthey; ABSpurdle; MRStratton; JPStruewing; DThompson; RATollenaar; AUitterlinden; Avan den Ouweland; HCWang; NWareham; SWedrén; PEWu; KYYoo; JZhang;

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