Top 20 of Hyperalgesia

Article title # Publications/# Citations

A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia.

1988: FBrown; RDubner; CFlores; KHargreaves; JJoris;


A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man.

1988: GJBennett; YKXie;


Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia.

2000: KAtkinson; SBingham; CClapham; PTDavey; JBDavis; EGrau; JGray; MJGunthorpe; ... AJHarper; MHHarries; JPHatcher; SAHughes; JLatcham; POverend; PLPugh; KRance; ARandall; DCRogers; SASheardown;


Spared nerve injury: an animal model of persistent peripheral neuropathic pain.

2000: IDecosterd; CJWoolf;


p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia.

2002: RRJi; SXJin; TASamad; RSchmoll; CJWoolf;


Central sensitization: a generator of pain hypersensitivity by central neural plasticity.

2009: ALatremoliere; CJWoolf;


An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.

2002: AAl-Hayani; TBisogno; CJChu; SNDavies; LDe Petrocellis; VDi Marzo; FFezza; PGeppetti; ... SMHuang; JFKrey; JDMiller; TJPetros; MTognetto; MTrevisani; JMWalker;


Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy.

2003: JADeLeo; VRaghavendra; FTanga;


Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain.

2005: PAnand; RBirch; CBountra; GNBuell; MACasula; IPChessell; JEgerton; CBGrahames; ... PGreen; JPHatcher; JPHughes; ADMichel; MMurfin; WLPeck; JRichardson; YYiangou;


p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

2003: RRJi; SXJin; CJWoolf; ZYZhuang;


Central sensitization: implications for the diagnosis and treatment of pain.

2010: CJWoolf;


Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord.

2008: JKCheng; RRJi; YKawasaki; LZhang;


Mechanisms of neuropathic pain.

2006: JNCampbell; RAMeyer;


Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats.

2003: JBiedenkapp; MChacur; SFMaier; DMartin; EDMilligan; KO'Connor; SPoole; KTracey; CTwining; LRWatkins;


Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.

1997: BJAllen; RSDaughters; JRGhilardi; PHonoré; DALappi; JLi; PWMantyh; SDRogers; DASimone; RGWiley;


Basic and clinical aspects of visceral hyperalgesia.

1994: GFGebhart; EAMayer;


Models and mechanisms of hyperalgesia and allodynia.

2009: JSandkühler;


Chronic hyperalgesia induced by repeated acid injections in muscle is abolished by the loss of ASIC3, but not ASIC1.

2003: NMBreese; MPPrice; KASluka; CLStucky; MJWelsh; JAWemmie;


Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma.

1997: AIBasbaum; CChen; ABMalmberg; STonegawa;


A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.

1999: KOAley; JDadgar; PGGreen; CWHodge; BHundle; WIsenberg; SGKhasar; JDLevine; ... YHLin; AMartin; GMcCarter; TMcMahon; ROMessing; DWang;