Top 20 of Hypothalamic Diseases

Article title # Publications/# Citations

MeCP2, a key contributor to neurological disease, activates and represses transcription.

2008: MChahrour; SYJung; JQin; CShaw; STWong; XZhou; HYZoghbi;

351

Recombinant human leptin in women with hypothalamic amenorrhea.

2004: JBullen; JLChan; AMDePaoli; AKaralis; CSMantzoros; RMurphy; PSmith; CKWelt;

124

Glutamate and the pathophysiology of hypoxic--ischemic brain damage.

1986: JWOlney; SMRothman;

86

Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human.

1998: AGiustina; JDVeldhuis;

83

GLI3 frameshift mutations cause autosomal dominant Pallister-Hall syndrome.

1997: LGBiesecker; JMGraham; SKang; AHOlney;

64

Brain fatty acid synthase activates PPARalpha to maintain energy homeostasis.

2007: MVChakravarthy; TColeman; ZHu; MDLane; MLópez; CFSemenkovich; AVidal-Puig; MWolfgang; ... DFWozniak; LYin; YZhu;

58

Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity.

2002: PAnderson; RLDobbins; EGomez-Sanchez; GMajdic; JDMcGarry; KLParker; LSSzczepaniak; MYoung;

54

Testicular biopsy score count--a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males.

1970: SGJohnsen;

44

Leptin in human physiology and pathophysiology.

2011: MBrinkoetter; TADardeno; OPHamnvik; SYKim; AKoniaris; FMagkos; CSMantzoros; ESienkiewicz;

41

Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa.

2005 Jul 2-8: JLChan; CSMantzoros;

41

Molecular and clinical analyses of Greig cephalopolysyndactyly and Pallister-Hall syndromes: robust phenotype prediction from the type and position of GLI3 mutations.

2005: MHAbbott; DJAughton; ASAylsworth; MJBamshad; LGBiesecker; GCBlack; CBooth; LBrueton; ... CJCurry; ADavid; MBDinulos; EElson; DBFlannery; MAFox; JMGraham; DKGrange; AEGuttmacher; MCHannibal; WHenn; RCHennekam; LBHolmes; HEHoyme; JJJohnston; CKilloran; KALeppig; AELin; PMacLeod; DKManchester; CMarcelis; LMazzanti; EMcCann; MTMcDonald; NJMendelsohn; JBMoeschler; BMoghaddam; GNeri; RNewbury-Ecob; IOlivos-Glander; RAPagon; KFPeters; JAPhillips; LSSadler; JMStoler; DTilstra; JTTurner; CMWalsh Vockley; EHZackai; TMZadeh;

39

Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome.

2008: KGHellemans; NLan; JHSliwowska; JWeinberg;

36

Stress responsive neurohormones in depression and anxiety.

2003: FHolsboer; AStröhle;

35

Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders.

2003: DDBelsham; FCai; HCui; AMSalapatek; LShkreta; SRSmukler;

31

Pallister-Hall syndrome phenotype in mice mutant for Gli3.

2002: JBöse; LGrotewold; URüther;

30

Leptin is an effective treatment for hypothalamic amenorrhea.

2011: KArampatzi; MTBrinkoetter; JPChamberland; SHChou; CGao; HGong; XLiu; CSMantzoros; GMatarese; RStefanakis;

29

Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study.

2003: WISE study group; CNBairey Merz; SLBerga; VBittner; GDBraunstein; TKHodgson; BDJohnson; SFKelsey; ... KAMatthews; CJPepine; GMPohost; NReichek; SEReis; WJRogers; BLSharaf; GSopko;

27

Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial.

2003: RKChristensen; PSHinds; SCKaste; SYLensing; RHLustig; SNRai; KRingwald-Smith; RESchreiber; SWu; XXiong;

26

Obesity: genes, brain, gut, and environment.

2009: UNDas;

25

Proton versus photon radiotherapy for common pediatric brain tumors: comparison of models of dose characteristics and their relationship to cognitive function.

2008: CHHua; TEMerchant; SNill; UOelfke; HShukla; XYing;

23