Top 20 of Medulloblastoma

Article title # Publications/# Citations

Identification of human brain tumour initiating cells.

2004: JBayani; IDClarke; MDCusimano; PBDirks; CHawkins; RMHenkelman; THide; SKSingh; JASquire;

1067

Identification of a cancer stem cell in human brain tumors.

2003: VEBonn; IDClarke; PBDirks; CHawkins; SKSingh; JSquire; MTerasaki;

682

Altered neural cell fates and medulloblastoma in mouse patched mutants.

1997: LVGoodrich; KMHiggins; LMilenkovic; MPScott;

356

Prediction of central nervous system embryonal tumour outcome based on gene expression.

2002: JCAllen; MAngelo; JABiegel; PMBlack; ACalifano; TCurran; MGaasenbeek; TRGolub; ... LCGoumnerova; JYKim; ESLander; CLau; DNLouis; MEMcLaughlin; JPMesirov; SMukherjee; JMOlson; TPoggio; SLPomeroy; RRifkin; GStolovitzky; LMSturla; PTamayo; CWetmore; DZagzag;

284

The prognostic role of a gene signature from tumorigenic breast-cancer cells.

2007: GYChen; MFClarke; PDalerba; AGurney; THoey; JLewicki; RLiu; KShedden; GSherlock; XWang;

217

Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449.

2009: CACallahan; BColeman; FJde Sauvage; LFu; SEGould; CLHann; THolcomb; JLaterra; ... PMLoRusso; JALow; CMRudin; JStinson; DDVon Hoff; RLYauch;

169

The genetic landscape of the childhood cancer medulloblastoma.

2010: MSBerger; CBettegowda; JABiegel; DDBigner; ZABinder; SMBoca; PCBurger; HCarter; ... CClara; TCurran; HSFriedman; DWFults; GLGallia; DSGerhard; JHartigan; YHe; GIJallo; SJones; ARJudkins; RKarchin; STKeir; KWKinzler; RJLeary; MLi; JCLin; SKMarie; RMcLendon; JEMinturn; YNikolsky; PANorthcott; NPapadopoulos; GParmigiani; DWParsons; PCPhillips; BARasheed; ACResnick; GJRiggins; JSamayoa; SMShinjo; DRSmith; PBStorm; MDTaylor; SVandenberg; VEVelculescu; BVogelstein; HYan; XZhang;

161

Medulloblastoma growth inhibition by hedgehog pathway blockade.

2002: PABeachy; DMBerman; JKChen; MKCooper; CGEberhart; ARHallahan; SSKarhadkar; JMOlson; ... JIPritchard; JTaipale; DNWatkins;

156

Metagenes and molecular pattern discovery using matrix factorization.

2004: JPBrunet; TRGolub; JPMesirov; PTamayo;

153

Medulloblastoma comprises four distinct molecular variants.

2010: EBouffet; SCClifford; CGEberhart; PFrench; CEHawkins; THielscher; AKorshunov; SMack; ... PANorthcott; SPfister; JTRutka; MDTaylor; HWitt;

152

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.

2000: ABerns; JJonkers; SMarino; Hvan der Gulden; MVooijs;

141

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

2009: CPAhn; BAlicke; JFBazan; CACallahan; FJde Sauvage; GJDijkgraaf; SEGould; CLHann; ... THolcomb; TJanuario; ZKan; JALow; KPujara; CMRudin; SSeshagiri; JStinson; TTang; RLYauch;

139

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations.

2006: AAdesina; DMAshley; MChintagumpala; TCurran; JDalton; DFinkelstein; CFuller; AGajjar; ... RJGilbertson; TLHogg; SJKellie; CCLau; MDTaylor; MCThompson;

137

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features.

2008: JBunt; HNCaron; SCClifford; JCloos; DEllison; WGrajkowska; WHartmann; NEHasselt; ... MKool; JKoster; ALakeman; NSMeeteren; AMrsic; TPietsch; DTroost; Pvan Sluis; RVersteeg; BYlstra;

133

Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors.

2006: JChun; CGEberhart; XFan; LKhaki; YMLi; WMatsui; DStearns;

128

Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors.

2003: MDCole; AMKenney; DHRowitch;

125

Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas.

2004: CLeung; MLingbeek; JLiu; SMarino; PSaremaslani; OShakhova; ETanger; Mvan Lohuizen;

120

A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors.

2003: JAChan; MWKieran; RSKlein; ALKung; ADLuster; JBRubin; KSchmidt; RASegal; YSun;

119

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma.

2008: AÁlvarez-Buylla; AKDillon; YGHan; VMHeine; EHuillard; ATKho; AHLigon; KLLigon; ... QMa; JMao; APMcMahon; YQian; DHRowitch; USchüller; TSun;

116

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.

2008: MBourboulas; TEllis; GFishell; JDKessler; RMachold; SLMarkant; TARead; DHRowitch; ... USchüller; BJWainwright; RJWechsler-Reya; ZJYang;

116