Top 20 of Neoplasms, Experimental

Article title # Publications/# Citations

The hallmarks of cancer.

2000: DHanahan; RAWeinberg;

3507

Tumor angiogenesis: therapeutic implications.

1971: JFolkman;

947

Establishment in culture of pluripotential cells from mouse embryos.

1981: MJEvans; MHKaufman;

835

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours.

1992: ABradley; JSButel; LADonehower; MHarvey; MJMcArthur; CAMontgomery; BLSlagle;

826

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2.

2004: DCarvajal; ZFilipovic; NFotouhi; BGraves; UKammlott; CKlein; NKong; EALiu; ... CLukacs; FPodlaski; LTVassilev; BTVu;

749

ras genes.

1987: MBarbacid;

699

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975: GBlobel; BDobberstein;

661

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981: GRMartin;

596

Stat3 as an oncogene.

1999: CAlbanese; JFBromberg; JEDarnell; GDevgan; RGPestell; MHWrzeszczynska; YZhao;

536

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene.

1996: KCarver-Moore; HChen; MDowd; NFerrara; KJHillan; LLu; MWMoore; KSO'Shea; LPowell-Braxton;

506

Tumor spectrum analysis in p53-mutant mice.

1994: RTBronson; SHalachmi; TJacks; LRemington; EMSchmitt; RAWeinberg; BOWilliams;

500

A dye-buoyant-density method for the detection and isolation of closed circular duplex DNA: the closed circular DNA in HeLa cells.

1967: WBauer; RRadloff; JVinograd;

478

Nitric oxide and macrophage function.

1997: JMacMicking; CNathan; QWXie;

471

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.

1997: JRBirkhead; TBoehm; EFlynn; JFolkman; NFukai; WSLane; MSO'Reilly; BROlsen; YShing; GVasios;

461

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

1986: HMaeda; YMatsumura;

432

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.

1983: AMDvorak; HFDvorak; SJGalli; VSHarvey; CAPerruzzi; DRSenger;

417

Biology of natural killer cells.

1989: GTrinchieri;

405

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo.

1993: MArmanini; NFerrara; NGillett; KJKim; BLi; HSPhillips; JWiner;

404

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.

1995: CDeng; SJElledge; JWHarper; PLeder; PZhang;

390

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.

1997: MABlasco; RADepinho; CWGreider; MPHande; PMLansdorp; HWLee; ESamper;

386